439695-64-4

Upstream product

• 336105-23-8 (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 591-51-5 phenyllithium 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 104-88-1 4-chlorobenzaldehyde 
• 100-52-7 benzaldehyde 
• 109674-45-5 4-methyl-2,6-dioxo-8-phenylhexahydro-[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide 
• 507469-89-8 (R)-(-)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide 
• 143-66-8 sodium tetraphenyl borate 

Downstream Products

• 451503-28-9 (α¹R)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 

Relevant academic research and scientific papers

Rhodium-catalyzed asymmetric arylation of N -(tert -butanesulfinyl)imines with sodium tetraarylborates

A diastereoselective rhodium-catalyzed arylation of N-(tert-butanesulfinyl) imines with sodium tetraarylborates is described. This method is general for constructing various chiral α-branched amines and 2-substituted pyrrolidines with high diastereoselectivity. A practical asymmetric approach to access chiral amines has been developed involving the use of air-stable Rh catalysts and reagents and in the absence of an external ligand.

Asymmetric Rh(I)-catalyzed addition of MIDA boronates to N-Tert -butanesulfinyl aldimines: Development and comparison to trifluoroborates

The Rh(I)-catalyzed addition of alkenyl and aryl MIDA boronates to N-tert-butanesulfinyl aromatic and aliphatic imines proceeds in good yields (up to 99%) and with very high selectivity (98:2 to >99:1). In comparison to trifluoroborates, higher yields and

Asymmetric synthesis of cetirizine dihydrochloride

Practical route technology for the preparation of (S)-cetirizine·2HCl via diastereoselective organometallic addition to N-tert-butanesulfinyl aldimines is disclosed.

Asymmetric synthesis of diarylmethylamines by diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines: Switchover of diastereofacial selectivity

Diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines gave alkylated adducts in high yields and diastereoselectivities. Cleavage of the chiral auxiliary under mildly acidic conditions gave diarylmethylamines in high yi