439695-64-4

Upstream product

• 336105-23-8 (R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 591-51-5 phenyllithium 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 104-88-1 4-chlorobenzaldehyde 
• 109674-45-5 4-methyl-2,6-dioxo-8-phenylhexahydro-[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide 
• 507469-89-8 (R)-(-)-N-(4-chlorobenzylidene)-2-methylpropane-2-sulfinamide 
• 143-66-8 sodium tetraphenyl borate 
• 100-52-7 benzaldehyde 

Downstream Products

• 451503-28-9 (α¹R)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 

Relevant academic research and scientific papers

Rhodium-catalyzed asymmetric arylation of N -(tert -butanesulfinyl)imines with sodium tetraarylborates

A diastereoselective rhodium-catalyzed arylation of N-(tert-butanesulfinyl) imines with sodium tetraarylborates is described. This method is general for constructing various chiral α-branched amines and 2-substituted pyrrolidines with high diastereoselectivity. A practical asymmetric approach to access chiral amines has been developed involving the use of air-stable Rh catalysts and reagents and in the absence of an external ligand.

Asymmetric Rh(I)-catalyzed addition of MIDA boronates to N-Tert -butanesulfinyl aldimines: Development and comparison to trifluoroborates

The Rh(I)-catalyzed addition of alkenyl and aryl MIDA boronates to N-tert-butanesulfinyl aromatic and aliphatic imines proceeds in good yields (up to 99%) and with very high selectivity (98:2 to >99:1). In comparison to trifluoroborates, higher yields and

Asymmetric synthesis of diarylmethylamines by diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines: Switchover of diastereofacial selectivity

Diastereoselective addition of organometallic reagents to chiral N-tert-butanesulfinimines gave alkylated adducts in high yields and diastereoselectivities. Cleavage of the chiral auxiliary under mildly acidic conditions gave diarylmethylamines in high yi

Asymmetric synthesis of cetirizine dihydrochloride

Practical route technology for the preparation of (S)-cetirizine·2HCl via diastereoselective organometallic addition to N-tert-butanesulfinyl aldimines is disclosed.