439697-28-6Relevant academic research and scientific papers
Synthesis of neomycin-DNA/peptide nucleic acid conjugates
Charles,Arya, Dev P.
, p. 145 - 160 (2005)
Syntheses of neomycin conjugates of DNA and peptide nucleic acid (PNA) is reported. The DNA and PNA conjugates were prepared by coupling neomycin isothiocyanate with the amino group of DNA/PNA in order to form a thiourea linkage. The use of neomycin isoth
Probing the recognition surface of a DNA triplex: Binding studies with intercalator-neomycin conjugates
Xue, Liang,Xi, Hongjuan,Kumar, Sunil,Gray, David,Davis, Erik,Hamilton, Paris,Skriba, Michael,Arya, Dev P.
scheme or table, p. 5540 - 5552 (2011/03/22)
Thermodynamic studies on the interactions between intercalator-neomycin conjugates and a DNA polynucleotide triplex [poly(dA)·2poly(dT)] were conducted. To draw a complete picture of such interactions, naphthalene diimide-neomycin (3) and anthraquinone-ne
COMPOSITIONS AND METHODS USING AMINOGLYCOSIDES TO BIND DNA AND RNA
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Page/Page column 5; 9; 53; 110; 112; sheet 14; 50, (2008/06/13)
Disclosed are compositions and methods related to aminoglycoside dimers aminoglycoside conjugates, and their uses.
Reaching into the major groove of B-DNA: Synthesis and nucleic acid binding of a neomycin-Hoechst 33258 conjugate
Arya, Dev P.,Willis, Bert
, p. 12398 - 12399 (2007/10/03)
Synthesis of a neomycin-Hoechst 33258 conjugate is reported. The conjugate combines the ligands known to selectively bind in the duplex and the triplex groove. The conjugate stabilizes DNA duplex over DNA triplex. The conjugate selectively stabilizes the
Combining the best in triplex recognition: Synthesis and nucleic acid binding of a BQQ-neomycin conjugate
Arya, Dev P.,Xue, Liang,Tennant, Paul
, p. 8070 - 8071 (2007/10/03)
Synthesis of a BQQ-neomycin conjugate is reported. The conjugate combines two ligands, one known to intercalate triplexes (BQQ) and another known to bind in the triplex groove (neomycin). The conjugate stabilizes T·A·T, as well as mixed base DNA triplex,
Synthesis of aminoglycoside-DNA conjugates
Charles,Xue, Liang,Arya, Dev P.
, p. 1259 - 1262 (2007/10/03)
Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.
