439800-07-4Relevant academic research and scientific papers
Enantioselective synthesis of phosphinyl peptidomimetics via an asymmetric Michael reaction of phosphonic acids with acrylate derivatives
Lui, Xuewei,Hu, Eric,Tian, Xinrong,Mazur, Adam,Ebetino, Frank H.
, p. 212 - 222 (2007/10/03)
Asymmetric Michael reaction of phosphinic or aminophosphinic acids with acrylate derivatives afforded phosphinyl dipeptidomimetics in excellent yields (>90 percent). Chiral induction of substituents at the α-position of acrylate derivatives of Evans oxazolidinone type auxiliaries was obtained in moderate to excellent diastereomeric and enantiomeric excesses (50-98 percent). Pure diastereomers and enantiomers of phosphinyl dipeptidomimetics 16-19 were also successfully separated by HPLC.
