439814-87-6

Basic information

• Product Name: 4-BROMO-2-FLUOROBENZALDEHYDE DIMETHYL ACETAL
• Synonyms: 4-BROMO-2-FLUOROBENZALDEHYDE DIMETHYL ACETAL;4-Bromo-1-(dimethoxymethyl)-2-fluorobenzene;-2-fluorobenzene;4-Bromo-1-(dimethoxymethyl)
• CAS NO: 439814-87-6
• Molecular Formula: C₉H₁₀BrFO₂
• Molecular Weight: 249.08
• Product Categories: Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds
• Mol File: 439814-87-6.mol

Chemical Properties

• Boiling Point: 232.9°C at 760 mmHg
• Flash Point: 117.9°C
• Appearance: /
• Density: 1.442g/cm³
• Vapor Pressure: 0.0876mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: 4-BROMO-2-FLUOROBENZALDEHYDE DIMETHYL ACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FLUOROBENZALDEHYDE DIMETHYL ACETAL(439814-87-6)
• EPA Substance Registry System: 4-BROMO-2-FLUOROBENZALDEHYDE DIMETHYL ACETAL(439814-87-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 439814-87-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-fluorobenzaldehyde dimethyl acetal is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-2-fluorobenzaldehyde dimethyl acetal is employed as an intermediate for the production of pesticides and other agrochemicals. Its incorporation into these products enhances their effectiveness in controlling pests and diseases, thereby improving crop yields and food security.
Used as a Solvent or Reagent in Chemical Reactions:
4-Bromo-2-fluorobenzaldehyde dimethyl acetal also serves as a solvent or reagent in various chemical reactions. Its reactivity and compatibility with different chemical groups make it a valuable component in the synthesis of a wide range of organic compounds, including specialty chemicals and advanced materials.

InChI:InChI=1/C9H10BrFO2/c1-12-9(13-2)7-4-3-6(10)5-8(7)11/h3-5,9H,1-2H3

Upstream product

• 1435-52-5 2,5-dibromofluorobenzene 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 149-73-5 trimethyl orthoformate 
• 497-19-8 sodium carbonate 
• 67-56-1 methanol 

Downstream Products

• 439814-88-7 4-(dimethoxymethyl)-3-fluorobenzaldehyde 
• 1445901-02-9 N-[4-(4-acetyl-piperazin-1-yl)-2-fluoro-benzyl]-4-tert-butyl-N-cyclobutyl-benzenesulfonamide 
• 1445902-01-1 N-[4-(4-acetyl-piperazin-1-yl)-2-fluoro-benzyl]-N-cyclobutyl-4-trifluoromethyl-benzenesulfonamide 
• 1445901-11-0 N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-N-cyclobutyl-4-trifluoromethoxy-benzenesulfonamide 
• 1445908-80-4 N-[4-(4-acetyl-piperazin-1-yl)-2-fluoro-benzyl]-N-cyclobutyl-4-difluoromethoxy-benzenesulfonamide 
• 1445901-24-5 N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-2,4-dichloro-N-cyclobutylbenzenesulfonamide 
• 1445901-31-4 N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-N-cyclobutyl-4-methoxybenzenesulfonamide 
• 1445901-51-8 N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-4-cyano-N-cyclobutylbenzenesulfonamide 
• 1445901-15-4 N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-N-cyclobutyl-3-methoxybenzenesulfonamide 
• 1445902-00-0 N-[4-(4-acetyl-piperazin-1-yl)-2-fluoro-benzyl]-N-cyclobutyl-3,5-difluorobenzenesulfonamide 
• 1445901-64-3 N-[4-(4-acetyl-piperazin-1-yl)-2-fluorobenzyl]-N-cyclobutyl-1-(3,5-dichloro-phenyl)methanesulfonamide 
• 1445901-70-1 N-[4-(4-acetyl-piperazin-1-yl)-2-fluoro-benzyl]-1-(4-chloro-phenyl)-N-cyclobutylmethanesulfonamide 
• 1445902-08-8 N-[4-(4-acetyl-piperazin-1-yl)-2-fluoro-benzyl]-4-chloro-N-cyclobutylbenzenesulfonamide 
• 1445901-73-4 N-[4-(4-acetyl-piperazin-1-yl)-2-fluoro-benzyl]-N-cyclobutyl-1-(3-chlorophenyl)-methanesulfonamide 

Relevant articles and documents

Synthesis and Transformations of Functionalized Benzosiloxaboroles

The synthesis and characterization of a series of fluorinated benzosiloxaboroles bearing synthetically useful formyl and cyano groups is reported. These compounds have been obtained by multistep syntheses starting with simple halogenated benzenes. The general synthetic protocol was based on the generation of ortho-boronated aryldimethylsilanes which undergo dehydrogenative cyclization upon hydrolytic workup due to activation of the Si–H bond by the adjacent boronic group. In some cases the synergy of adjacent boron- and silicon-based functionalities resulted in an unexpected hydrosilylation of the CHO group under mild aqueous conditions. The reduction of a benzosiloxaborole derivative bearing the formyl group at the ortho position with respect to the boron atom resulted in a structural transformation reflecting the higher stability of the carboxaborole heterocycle with respect to its silicon counterpart. Thus, a unique heterocyclic system featuring a central 10-membered ring comprising two borasiloxane linkages was isolated.

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Therapeutic diphenyl ether ligands

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