439904-24-2

Upstream product

• 541-16-2 t-butyl malonate 
• 14192-13-3 methyl 2,5-diiodobenzoate 
• 14192-12-2 2,5-diiodobenzoic acid 

Downstream Products

• 640735-68-8 fluoropropanedioic acid, 4-iodo-2-(methoxycarbonyl)phenyl-, bis(1,1-dimethylethyl) ester 
• 439904-27-5 2-{4-[2-acetylamino-2-(1-biphenyl-4-ylmethyl-2-oxo-azepan-3-ylcarbamoyl)-ethyl]-2-methoxycarbonyl-phenyl}-malonic acid di-tert-butyl ester 
• 439904-26-4 [4-[2-(acetylamino)-3-[[(3S)-1-[[1,1'-(biphenyl)-4-yl]methyl]-2-oxohexahydro-1H-azepin-3-yl]amino]-3-oxo-1-propenyl]-2-(methoxycarbonyl)phenyl]propanedioic acid 1,3-bis(1,1-dimethylethyl) ester 
• 439904-23-1 2-{4-[2-Acetylamino-2-((S)-1-biphenyl-4-ylmethyl-2-oxo-azepan-3-ylcarbamoyl)-ethyl]-2-carboxy-phenyl}-malonic acid 
• 439904-25-3 [4-[2-(acetylamino)-2-carboxyethenyl]-2-(methoxycarbonyl)phenyl]propanedioic acid 1,3-bis(1,1-dimethylethyl) ester 
• 871112-17-3 fluoropropanedioic acid,[4-[2-(acetylamino)-3-[[(3S)-1-[(1,1-biphenyl)-4-yl]methyl-hexahydro-2-oxo-1H-azepin-3-yl]amino]-3-oxo-1-propenyl]-2-(methoxycarbonyl)phenyl]-, bis(1,1-dimethylethyl) ester 
• 640735-69-9 2-[4-(2-acetylamino-2-methoxycarbonyl-vinyl)-2-methoxycarbonyl-phenyl]-2-fluoro-malonic acid di-tert-butyl ester 
• 640735-73-5 fluoropropanedioic acid, 4-[2-(acetylamino)-2-carboxyethenyl]-2-(methoxycarbonyl)phenyl-, bis(1,1-dimethylethyl) ester 
• 476212-91-6 2-[4-(2-acetylamino-2-methoxycarbonyl-vinyl)-2-methoxycarbonyl-phenyl]-malonic acid di-tert-butyl ester 

Relevant academic research and scientific papers

SAR and x-ray. A new approach combining fragment-based screening and rational drug design: Application to the discovery of nanomolar inhibitors of Src SH2

pp60Src is a protein involved in signal transduction and is mainly expressed in neurones, platelets, and osteoclasts. Its precise biological role was recently discovered with the KO experiments by Soriano that gave rise to no other apparent phe