14192-13-3Relevant articles and documents
Measurement of long-range interatomic distances by solid-state tritium-NMR spectroscopy
Yuen, Alexander K. L.,Lafon, Olivier,Charpentier, Thibault,Roy, Myriam,Brunet, Francine,Berthault, Patrick,Sakellariou, Dimitrios,Robert, Bruno,Rimsky, Sylvie,Pillon, Florence,Cintrat, Jean-Christophe,Rousseau, Bernard
supporting information; experimental part, p. 1734 - 1735 (2010/04/25)
(Chemical Equation Presented) For the structural determination of a ligand bound to an amorphous macromolecular system, solid-state NMR can be used to provide interatomic distances. It is shown here that selective labeling in discrete locations with tritium enables accurate measurement of long-range distances owing to the high gyromagnetic ratio of this nucleus, without structural modification of the molecule. This approach gives access to the largest NMR distance ever measured between two nuclei (14.4 A). 3H MAS NMR appears to be a promising tool for structural applications in the biological and material sciences. Copyright
SAR and x-ray. A new approach combining fragment-based screening and rational drug design: Application to the discovery of nanomolar inhibitors of Src SH2
Lesuisse, Dominique,Lange, Gudrun,Deprez, Pierre,Bénard, Didier,Schoot, Bernard,Delettre, Georges,Marquette, Jean-Pierre,Broto, Pierre,Jean-Baptiste, Véronique,Bichet, Paulette,Sarubbi, Edoardo,Mandine, Eliane
, p. 2379 - 2387 (2007/10/03)
pp60Src is a protein involved in signal transduction and is mainly expressed in neurones, platelets, and osteoclasts. Its precise biological role was recently discovered with the KO experiments by Soriano that gave rise to no other apparent phe
ATTOGRAM-LEVEL DETECTION AND RELATIVE RESPONSE OF STRONG ELECTROPHORES BY GAS CHROMATOGRAPHY WITH ELECTRON CAPTURE DETECTION.
Corkill,Joppich,Kuttab,Giese
, p. 481 - 485 (2007/10/02)
The responses as peak areas of some divergent compounds, most of which are strong electron absorbers, are measured by gas chromatography with electron capture detection (GC-ECD). The most sensitive compounds are derivatized lodothyronines, which are essentially 20-fold more sensitive than lindane. N,N-Dipentafluorobenzoylpentafluoroaniline, a somewhat less sensitive but more volatile substance, was selected for determination of a detection limit. The value was 90 ag(1. 6 multiplied by 10** minus **1**9 mol), largely due to an anomalous increase in its response at the trace level. This increases the reported sensitivity of GC-ECD by 100-fold.
