439912-32-0

Upstream product

• 35718-08-2 propargyl chloroformate 
• 771-61-9 2,3,4,5,6-pentafluorophenol 

Downstream Products

• 439912-50-2 3-phenyl-2-prop-2-ynyloxycarbonylamino-propionic acid 
• 439912-45-5 ((prop-2-yn-1-yloxy)carbonyl)-L-phenylalanine 
• 50903-50-9 N-[(1,1-dimethylethoxy)carbonyl]-L-leucine pentafluorophenyl ester 
• 439912-40-0 (S)-3-Methyl-2-prop-2-ynyloxycarbonylamino-butyric acid pentafluorophenyl ester 
• 439912-39-7 (S)-3-Phenyl-2-prop-2-ynyloxycarbonylamino-propionic acid pentafluorophenyl ester 
• 1252806-46-4 C₃₈H₃₁NO₁₁ 
• 1252806-45-3 C₃₈H₃₁NO₁₁ 
• 50903-52-1 (tert-butoxycarbonyl)-L-proline pentafluorophenol ester 

Relevant academic research and scientific papers

Simultaneous protection and activation of amino acids using propargyl pentafluorophenyl carbonate

A very efficient method for the simultaneous protection of the amino group and activation of the carboxyl group of amino acids is reported using propargyl pentafluorophenyl carbonate (PocOPfp). The amino group is protected as a propargyloxycarbonyl (Poc) derivative, and the carboxyl group is activated as a pentafluorophenyl ester. The yields obtained are good to excellent ranging from 60 to 87%.

Synthesis and applications of propargyl pentafluorophenyl carbonate for peptide synthesis

Propargyl pentafluorophenyl carbonate was synthesised in quantitative yield by the reaction of propargyl chloroformate and pentafluorophenol. All the N-propargyloxycarbonyl (N-Poc) amino acids were obtained in good yield. The use of Poc-OPfp in peptide synthesis has been explored.