439916-24-2Relevant academic research and scientific papers
Rearrangement of Hydroxylated Pinene Derivatives to Fenchone-Type Frameworks: Computational Evidence for Dynamically-Controlled Selectivity
Blümel, Marcus,Nagasawa, Shota,Blackford, Katherine,Hare, Stephanie R.,Tantillo, Dean J.,Sarpong, Richmond
, p. 9291 - 9298 (2018)
An acid-catalyzed Prins/semipinacol rearrangement cascade reaction of hydroxylated pinene derivatives that leads to tricyclic fenchone-type scaffolds in very high yields and diastereoselectivity has been developed. Quantum chemical analysis of the selecti
Synthesis of 5-azaindoles via a cycloaddition reaction between nitriles and donor-acceptor cyclopropanes
Moustafa, Mahmoud M. Abd Rabo,Pagenkopf, Brian L.
supporting information; scheme or table, p. 3168 - 3171 (2010/09/10)
(Figure Presented) A new method for the synthesis of 5-azaindole derivatives is reported. A [3+2] dipolar cycloaddition between nitriles and a 3,4-cyclopropanopiperidine followed by SeO2 oxidation affords the target compounds in moderate to excellent yields. The divergent nature and cost effectiveness of this method makes it very suitable for combinatorial applications in the pharmaceutical industry.
