440111-01-3Relevant academic research and scientific papers
Aryl Fluorosulfate Trapped Staudinger Reduction
Ren, Gerui,Zheng, Qinheng,Wang, Hua
, p. 1582 - 1585 (2017)
A chemoselective Staudinger reduction/sulfur(VI) fluoride exchange cascade has been developed to join two chemical segments through an aryl sulfamate ester (RNH-SO2-OAr) linkage. Aryl fluorosulfate is exploited in this work as the first tetrahe
METHOD FOR PROTEIN PURIFICATION AND LABELING BASED ON A CHEMOSELECTIVE REACTION
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Page/Page column 30, (2010/10/20)
The present invention relates to methods and reagents for labeling a target compound and a chemoselective reaction that simultaneously cleaves and ligates different labels to a target compound. Such reagents are phosphines of formula (1) wherein A is a gr
Water soluble phosphines Part XV. Syntheses of multiply functionalized and chiral phospine ligands by Pd-catalyzed P-C and C-C coupling reactions
Brauer, David J.,Hingst, Martin,Kottsieper, Konstantin W.,Liek, Christian,Nickel, Thomas,Tepper, Michael,Stelzer, Othmar,Sheldrick, William S.
, p. 14 - 26 (2007/10/03)
Phosphine ligands containing mono- and multiply substituted aromatic substituents (1-13, 19a and 19b) are accessible in high yields by palladium-catalyzed P-C coupling reactions between primary, secondary or disecondary phosphines and iodo- or bromoaromatic compounds. The reaction is of broad applicability and compatible with electron donor or electron acceptor substituents in ortho, meta or para position to the halogen in the aromatic ring systems. It may be performed in protic and aprotic solvents. The chiral spirocyclic boronato complex 15a is formed upon reaction of 3 with boric acid, while with benzeneboronic acid 15c with a peripheral Lewis acid group is obtained. The Pd-mediated P-C coupling reaction of primary phosphines proceeds stepwise, tailor-made chiral secondary (16) and tertiary phosphines (17) being formed in high yield. Through combination with Suzuki-type C-C coupling reactions, the scope of Pd-catalyzed P-C coupling may be extended further, novel ligands (20a, 20b, 21a, 21b) with biphenylyl substituents being accessible. The X-ray structures of the salicylic acid derivative 3 (space group P1) and of ortho-iso-propylphenyl-diphenylphosphine 6 (space group Pbca) have been determined.
