440116-79-0Relevant academic research and scientific papers
An efficient synthesis of quinoxaline derivatives mediated by stannous chloride
Shi, Da-Qing,Dou, Guo-Lan,Ni, Sai-Nan,Shi, Jing-Wen,Li, Xiao-Yue
experimental part, p. 1797 - 1801 (2009/05/31)
(Chemical Equation Presented) Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields by the reaction of 1,2-diketones and 2-nitroaniline, benzofuroxan or 1,2-dinitrobenzene promoted by SnCl2·2H2O. The role of stannous chloride is acting as both reductive agent and catalyst in this synthesis. This new method has the advantages of accessible starting materials, convenient manipulation, short reaction time and high yields.
Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution
Zhang, Li,Qiu, Beiying,Li, Xin,Wang, Xin,Li, Jingya,Zhang, Yongliang,Liu, Jian,Li, Jia,Shen, Jingkang
, p. 988 - 999 (2007/10/03)
A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.
