440333-35-7Relevant academic research and scientific papers
Total synthesis of antimalarial diterpenoid (+)-kalihinol A
Miyaoka, Hiroaki,Abe, Yasunori,Sekiya, Nobuaki,Mitome, Hidemichi,Kawashima, Etsuko
, p. 901 - 903 (2012/02/04)
Total synthesis of antimalarial diterpenoid (+)-kalihinol A, isolated from marine sponge Acanthella sp., is achieved. This total synthesis involves regioselective alkylation of an epoxide, construction of a tetrahydropyran ring by iodo-etherification, construction of a cis-decalin ring by intramolecular Diels-Alder reaction, isomerization of cis-decalin to trans-decalin, and subsequent functionalization of the trans-decalin ring.
Total synthesis of marine diterpenoid kalihinene X
Miyaoka, Hiroaki,Shida, Hiroshi,Yamada, Naohito,Mitome, Hidemichi,Yamada, Yasuji
, p. 2227 - 2230 (2007/10/03)
Total synthesis of marine diterpenoid kalihinene X was achieved. This total synthesis involves regioselective coupling reaction of carbanion of alkyl sulfone with epoxyalcohol and construction of cis-decalin ring by intramolecular Diels-Alder reaction. The absolute configuration of kalihinene X could be determined by this total synthesis.
