440345-53-9

Upstream product

• 440345-54-0 methyl 2-azido-3-O-benzyl-2-deoxy-4,6-O-benzylidine-D-glucopyranoside 
• 100-39-0 benzyl bromide 
• 274260-02-5 methyl 2-azido-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside 
• 14131-68-1 N-acetyl-D-glucosamine 
• 3946-01-8 methyl N-acetyl-β-D-glucosaminide 
• 132488-48-3 methyl 2-acetamido-2-deoxy-4,6-O-(4-methoxybenzylidene)-β-D-glucopyranoside 
• 81927-56-2 methyl 4,6-O-benzylidene-2-deoxy-2-phthalimide-β-D-glucopyranoside 
• 81927-58-4 methyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-phthalimido-β-D-glucopyranoside 
• 76101-14-9 methyl-2-desoxy-2-phthalimido-β-D-glucopyranoside 
• 97242-85-8 methyl 3-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranoside 

Downstream Products

• 440345-47-1 methyl 2-azido-3-O-benzyl-2-deoxy-6-O-tert-butyldimethylsilyl-2-deoxy-β-D-glucopyranoside 
• 440345-48-2 Acetic acid (2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-5-azido-4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-tetrahydro-pyran-3-yloxy]-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-3-yl ester 
• 440345-52-8 methyl 2-acetamido-2-deoxy-3-O-benzyl-4-O-(3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-2',6-di-O-(methane-1,2-diyl)-β-D-glucopyranoside 
• 440345-49-3 methyl 2-azido-2-deoxy-3-O-benzyl-4-O-(2-O-acetyl-3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside 
• 440345-50-6 methyl 2-azido-2-deoxy-3-O-benzyl-4-O-(3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-β-D-glucopyranoside 
• 440345-51-7 methyl 2-azido-2-deoxy-3-O-benzyl-4-O-(3,4,6-tri-O-benzyl-β-D-galactopyranosyl)-2',6-di-O-(methane-1,2-diyl)-β-D-glucopyranoside 

Relevant academic research and scientific papers

Selectively Deoxyfluorinated N-Acetyllactosamine Analogues as 19F NMR Probes to Study Carbohydrate-Galectin Interactions

Galectins are widely expressed galactose-binding lectins implied, for example, in immune regulation, metastatic spreading, and pathogen recognition. N-Acetyllactosamine (Galβ1-4GlcNAc, LacNAc) and its oligomeric or glycosylated forms are natural ligands of galectins. To probe substrate specificity and binding mode of galectins, we synthesized a complete series of six mono-deoxyfluorinated analogues of LacNAc, in which each hydroxyl has been selectively replaced by fluorine while the anomeric position has been protected as methyl β-glycoside. Initial evaluation of their binding to human galectin-1 and -3 by ELISA and 19F NMR T2-filter revealed that deoxyfluorination at C3, C4′ and C6′ completely abolished binding to galectin-1 but very weak binding to galectin-3 was still detectable. Moreover, deoxyfluorination of C2′ caused an approximately 8-fold increase in the binding affinity towards galectin-1, whereas binding to galectin-3 was essentially not affected. Lipophilicity measurement revealed that deoxyfluorination at the Gal moiety affects log P very differently compared to deoxyfluorination at the GlcNAc moiety.

A disaccharide intermediate fragment [...] BA and its synthetic method

The invention discloses a fondaparinux sodium disaccharide intermediate fragment BA and a synthetic method thereof. The synthetic method is novel in synthesis strategy, available in raw materials, relatively fewer in reaction steps, mild in reaction condi

α-(2,6)-sialyltransferase-catalyzed sialylations of conformationally constrained oligosaccharides

It is demonstrated that conformationally restricted oligosaccharides can act as acceptors for glycosyltransferases. Correlation of the conformational properties of N-acetyl lactosamine (Galβ/(1-4)GlcNAc, LacNAc) and several preorganized derivatives with t