440353-70-8 Usage
Molecular Structure
A benzonitrile group attached to a piperidine ring through a sulfonyl group.
Target Protein
Protein Tyrosine Phosphatase 1B (PTP1B)
Function
Potent and selective inhibitor of PTP1B
Role in Disease
Negative regulator of insulin and leptin signaling pathways, making it a potential target for the treatment of type 2 diabetes and obesity.
Therapeutic Potential
Effective in regulating glucose homeostasis and improving insulin sensitivity in animal models of diabetes. A promising candidate for the development of new drugs for the treatment of metabolic disorders and related diseases.
Ongoing Research
Further research is being conducted to explore the potential therapeutic applications of KAB320 and its mechanism of action.
Check Digit Verification of cas no
The CAS Registry Mumber 440353-70-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,0,3,5 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 440353-70:
(8*4)+(7*4)+(6*0)+(5*3)+(4*5)+(3*3)+(2*7)+(1*0)=118
118 % 10 = 8
So 440353-70-8 is a valid CAS Registry Number.
440353-70-8Relevant academic research and scientific papers
Arenesulfonylheterocycles (I): Synthesis and reactions of 2-benzenesulfonyl-4,5-dichloropyridazin-3-ones with amines
Kweon, Deok-Heon,Kim, Ho-Kyun,Kim, Jeum-Jong,Chung, Hyun A.,Woo, Song Lee,Kim, Sung-Kyu,Yoon, Yong-Jin
, p. 203 - 211 (2007/10/03)
The direct sulfonylation of 4,5-dichloropyridazin-3-ones with some benzenesulfonyl chlorides in the presence of base in tetrahydrofuran gave only the corresponding N-sulfonylated product. The reaction of 2-benzenesulfonyl-4,5-dichloropyridazin-3-ones with some aliphatic amines under neutral conditions afforded 5-alkylamino-2-benzenesulfonyl-4-chloropyridazin-3-ones and/or the corresponding N-alkyl-benzenesulfonamides.
