69360-26-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyanobenzenesulphonyl chloride is used as a synthetic intermediate for the production of various pharmaceuticals and drug candidates. Its unique chemical structure allows for the formation of diverse compounds with potential therapeutic applications.
Used in Organic Synthesis:
2-Cyanobenzenesulphonyl chloride is used as a key building block in the synthesis of complex organic molecules. Its reactivity and functional groups enable the formation of a wide range of chemical products.
Specific Applications:
2-Cyanobenzenesulphonyl chloride is used as a synthetic intermediate for the production of the following compounds:
2-butyl-5-(2-cyanophenyl)furan: 2-Cyanobenzenesulphonyl chloride may have potential applications in the development of new pharmaceuticals or as a chemical intermediate in organic synthesis.
2-(2-cyanophenyl)-3,6-dimethyl-4,5,6,7-tetrahydrobenzofuran: 2-Cyanobenzenesulphonyl chloride could be used in the synthesis of novel organic compounds or as a precursor in the development of new materials.
5-thia-4b,10-diaza-indeno[2,1-a]indene-5,5-dioxide: This unique compound may have potential applications in various fields, including pharmaceuticals, materials science, or as a chemical intermediate.
1-methyl-2-(2-cyanophenyl)pyrrole: 2-Cyanobenzenesulphonyl chloride can be used in the synthesis of various organic molecules, potentially leading to new chemical products or materials.

InChI:InChI=1/C7H4ClNO2S/c8-12(10,11)7-4-2-1-3-6(7)5-9/h1-4H

Upstream product

• 81-07-2 saccharin 
• 128-09-6 N-chloro-succinimide 
• 64-17-5 ethanol 
• 63216-04-6 o-benzyl mercapto-benzonitrile 
• 100-51-6 benzyl alcohol 

Downstream Products

• 81-07-2 saccharin 
• 2527-57-3 2,2'-dithiobisbenzamide 
• 69360-22-1 1,1-dioxo-2-p-tolyl-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-ylideneamine 
• 69360-23-2 2-(4-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-ylideneamine 
• 197959-92-5 3-(2-cyanophenylsulfonyloxy)-5-methylphenol 
• 204126-20-5 N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide 
• 7668-23-7 3-(phenylamino)benzo[d]isothiazole 1,1-dioxide 
• 60-29-7 diethyl ether 
• 75-00-3 chloroethane 
• 440352-73-8 2-(2-cyanobenzenesulfonyl)-4,5-dichloropyridazin-3-one 

Relevant academic research and scientific papers

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

Reactions of benzyl aryl sulfides with excess active halogen reagents

1,2,3-Tribromopyrrolo[1,2-b][1,2]benzothiazin-10-one (2) is produced from 2-[2-(benzylthio)benzoyl]-pyrrole (1) when treated with excess (5 equiv) NBS in CHCl3. With NCS, a mixture is obtained in which di- and trichloropyrrolo[1,2-b][1,2]benzothiazin-10-ones are present. If ethanol is present in the NCS reaction, compound 4 is formed as the major product. Further, compound 3 is also formed by the reaction of compound 1 or the corresponding disulfide with excess SOCl2. A novel route to alkyl arenesulfinic esters is also reported. Treatment of a benzyl aryl sulfide with excess (5 equiv) NCS in the presence of an n-alkyl alcohol (7 equiv) produces an n-alkyl arenesulfinic ester in good yield. An arenesulfonyl chloride is the major product in the presence of benzyl alcohol.

Process for the preparation of 2-fluorobenzonitrile from saccharin

The present invention relates to a process for the preparation of 2-fluorobenzonitrile. The process comprises the steps of: (a) heating saccharin and phosphorus pentachloride under conditions and for a time sufficient to provide 2-cyanobenzenesulfonyl chloride; and (b) reacting the 2-cyanobenzenesulfonyl chloride with alkali metal fluoride in solvent for said 2-cyanobenzenesulfonyl chloride under conditions and for a time sufficient to provide 2-fluorobenzonitrile. The present invention provides a process for the preparation of 2-fluorobenzonitrile which is a versatile intermediate for a variety of 2-fluoro substituted benzenes. For example, hydrolysis of 2-fluorobenzonitrile leads to 2-fluorobenzoic acid or 2-fluorobenzamide while reduction of 2-fluorobenzonitrile leads to 2-fluorobenzylamine. Also, the reaction of 2-fluorobenzonitrile with organometallic reagents results in various 2-fluorophenyl ketones.