440359-53-5

Basic information

• Product Name: 2-bromo-N-(2-hydroxy-3-methylphenyl)-5-methyl-3-thiophenecarboxamide
• Synonyms: 2-bromo-N-(2-hydroxy-3-methylphenyl)-5-methyl-3-thiophenecarboxamide
• CAS NO: 440359-53-5
• Molecular Weight: 326.214
• Mol File: 440359-53-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-(2-hydroxy-3-methylphenyl)-5-methyl-3-thiophenecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-(2-hydroxy-3-methylphenyl)-5-methyl-3-thiophenecarboxamide(440359-53-5)
• EPA Substance Registry System: 2-bromo-N-(2-hydroxy-3-methylphenyl)-5-methyl-3-thiophenecarboxamide(440359-53-5)

Safety Data

• Hazardous Substances Data: 440359-53-5(Hazardous Substances Data)

Upstream product

• 440359-58-0 2-ethoxycarbonyloxy-3-methoxycarbonylaminotoluene 
• 440359-59-1 3-t-butyloxycarbonyl-2,3-dihydro-7-methyl-3H-benzoxazole-2-one 
• 440359-60-4 3-t-butyloxycarbonylamino-2-hydroxytoluene 
• 221061-14-9 2-bromo-5-methylthiophene-3-carboxylic acid 
• 19156-50-4 5-methyl-thiophene-3-carboxylic acid 
• 83-40-9 3-methylsalicylic acid 
• 29421-92-9 4-bromo-2-methylthiophene 
• 40925-60-8 2,3-dihydro-7-methyl-3H-benzoxazole-2-one 
• 78886-51-8 2-methyl-6-aminophenol hydrochloride 
• 221060-79-3 2-Bromo-5-methyl-3-thiophenecarbonyl chloride 

Relevant articles and documents

Synthesis of thieno[2,3-b][1,5]benzoxazepine derivatives

A new series of 4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepines 1a-k has been synthesized from 4-bromo-2-methylthiophene 6 or ethyl 2-amino-4,5-dimethyl-3-thiophencarboxylate 10. Preparation of the key intermediate thieno[2,3-b][1,5]benzoxazepine-4(5H)-ones 4a-i, 4k were carried out by treatment of 2-bromo-N-(2-hydroxyphenyl)-3-thiophencarboxamides 5a-i, 5k with potassium carbonate in DMSO. Compounds 1 are thienoanalogues of loxapine, a potent antipsychotic drug. Of these compounds, the neuroleptic activity of 2-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepine 1a (R1, R3=H, R2=CH3) demonstrated potent antipsychotic activity.