440366-54-1Relevant articles and documents
Novel synthesis of [1-11C]γ-vinyl-γ-aminobutyric acid ([1-11C]GVG) for pharmacokinetic studies of addiction treatment
Zhang, Zongren,Ding, Yu-Shin,Studenov, Andrei R.,Gerasimov, Madina R.,Ferrieri, Richard A.
, p. 199 - 211 (2007/10/03)
γ-Vinyl-γ-aminobutyric acid (GVG, Vigabatrin), a suicide inhibitor of GABA-transaminase (GABA-T), has been suggested as a new drug for the treatment of substance abuse. In order to better understand its pharmacokinetics and potential side effects, we have developed a radiosynthesis of carbon-11 (t1/2=20min) labeled GVG for positron emission tomographic (PET) studies. We report here a novel synthetic strategy to prepare the precursor and to efficiently label GVG with C-11. 5-Bromo-3-(carbobenzyloxy)amino-1-pentene was synthesized in five steps from homoserine lactone, including reduction and methylenation. This was used in a one-pot, two-step radiosynthesis. Displacement of bromide with no-carrier-added [11C]cyanide followed by acid hydrolysis afforded [1-11C]GVG with decay corrected radiochemical yields of 27 ± 9% (n=6, not optimized) with respect to [11C]cyanide in a synthesis time of 45 min. Copyright
