440368-60-5

Upstream product

• 131543-46-9 Glyoxal 
• 19534-26-0 (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol hydrochloride 
• 119-62-0 (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol 

Downstream Products

• 1042072-64-9 (2R,2'R,4S,4'S,5S,5'S)-5,5'-bis-[(2,4-dichloro-s-triazin-6-yl)amino]-4,4'-bis(4-nitrophenyl)-2,2'-bi-1,3-dioxane 

Relevant academic research and scientific papers

Convenient Synthesis of Chiral 5-Amino-1,3-Dioxanes Built on Some 1-p-Nitrophenylserinols Skeletons

A simple and rapid methodology for the synthesis of the title compounds is described in order to access polychiral (enantiomerically pure) 5-aminodioxanes in satisfactory yields. The reaction of two nitrophenylserinols with two versatile carbonyl electrophiles (formaldehyde and glyoxal) in very strong acidic conditions (96% H2SO4) is discussed together with the limitations of the method.

Serinolic amino-s-triazines: Iterative synthesis of N-substituted amino-1,3-dioxane derivatives from l-(p-nitrophenyl)serinols and rotational stereochemistry phenomena

We report the first iterative and chemioselective approach towards the synthesis of highly elaborated N-substituted 2,4,6-triamino-s-triazines (melamines) and precursors, by amination of cyanuric chloride with anancomeric and enantiomerically pure primary