440659-02-9Relevant academic research and scientific papers
Facile synthesis of o- and p-(1-trifluoromethyl)-alkylated phenols via generation and reaction of quinone methides
Gong, Yuefa,Kato, Katsuya
, p. 431 - 434 (2002)
Several ortho- and para-(1-chloro-2,2,2-trifluoroethyl) phenols were prepared from the corresponding alcohols and thionyl chloride in the presence of pyridine. They reacted smoothly with sodium borohydride and Grignard reagents under mild conditions, forming 2,2,2-trifluoroethyl- or 1-trifluoromethylalkylphenols in high yields.
BETA-SECRETASE MODULATORS AND METHODS OF USE
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Page/Page column 169, (2010/11/27)
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula (I), or compositions including them, to a subject. The invention also comprises further embodiments of Formulas (II) and (III), intermediates and processes useful for the preparation of compounds of the invention.
Nucleophilic replacement of p-(1-chloro-2,2,2-trifluoroethyl)phenols: Novel synthesis of β-trifluoromethyl-tyrosine
Gong, Yuefa,Kato, Katsuya
, p. 141 - 146 (2007/10/03)
Three para -(1-chloro-2,2,2-trifluoroethyl)phenols 2a-c were prepared by selective α-chlorination of the corresponding alcohols 1a-c. Substitution of 2a by active methylene compound 4 proceeds smoothly in the presence of an appropriate base at room temper
