246245-20-5

Basic information

• Product Name: 4-(2,2,2-trifluoro-1-hydroxyethyl)phenol
• Synonyms: 4-(2,2,2-trifluoro-1-hydroxyethyl)phenol
• CAS NO: 246245-20-5
• Molecular Formula: C₈H₇F₃O₂
• Molecular Weight: 192.1351896
• Mol File: 246245-20-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 278.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.419±0.06 g/cm3(Predicted)
• PKA: 9.52±0.26(Predicted)
• CAS DataBase Reference: 4-(2,2,2-trifluoro-1-hydroxyethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2,2-trifluoro-1-hydroxyethyl)phenol(246245-20-5)
• EPA Substance Registry System: 4-(2,2,2-trifluoro-1-hydroxyethyl)phenol(246245-20-5)

Safety Data

• Hazardous Substances Data: 246245-20-5(Hazardous Substances Data)

Usage

General Description

4-(2,2,2-trifluoro-1-hydroxyethyl)phenol is a chemical compound with the molecular formula C8H7F3O2. It is a phenolic compound with a hydroxyethyl group and three fluorine atoms attached to the benzene ring. This chemical is used in various industrial and pharmaceutical applications, including as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It can also be used as a building block in the production of specialty chemicals and as a reagent in organic synthesis. Additionally, 4-(2,2,2-trifluoro-1-hydroxyethyl)phenol has potential uses as a solubilizer, emulsifier, or dispersant in formulations for paints, adhesives, and coatings. It is important to handle this chemical with care and according to safety guidelines due to its potential health and environmental hazards.

Upstream product

• 55605-84-0 trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal 
• 108-95-2 phenol 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 25244-30-8 4-(allyloxy)bromobenzene 
• 1279691-46-1 4-[1-(5-dimethylamino-naphthalene-1-sulfonyloxy)-2,2,2-trifluoro-ethyl]-phenyl acetate 
• 60-24-2 2-hydroxyethanethiol 
• 123-11-5 4-methoxy-benzaldehyde 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 403648-66-8 (±)-trimethyl-2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxysilane 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 1823-63-8 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one 

Downstream Products

• 1823-63-8 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one 
• 1429029-75-3 4-(1-hydroxy-2,2,2-trifluoroethyl)cyclohexanol 
• 86571-21-3 4-(2,2,2-trifluoroethyl)phenol 
• 635752-84-0 2-(benzhydrylidene-amino)-4,4,4-trifluoro-3-(4-hydroxy-phenyl)-butyric acid ethyl ester 
• 635752-86-2 4,4,4-trifluoro-3-(4-hydroxy-phenyl)-2-nitro-butyric acid ethyl ester 
• 440659-02-9 4-(1-chloro-2,2,2-trifluoroethyl)phenol 

Relevant articles and documents

Convenient synthesis of α-trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl α-trifluoroacetaldehyde hemiaminal

Aminofluoroalkylation of various heteroarenes or substituted benzenes with the N-trimethylsilyl hemiaminals, prepared from 1,1,1,3,3,3-hexamethyldisilazane and gaseous trifluoroacetaldehyde, smoothly underwent at room temperature in the presence of a Lewis acid. [(1-Aryl-2,2,2-trifluoro)ethyl]amines or bis[(1-aryl-2,2,2-trifluoro)ethyl]amines were afforded in moderate to high yields.

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula (I), or compositions including them, to a subject. The invention also comprises further embodiments of Formulas (II) and (III), intermediates and processes useful for the preparation of compounds of the invention.