246245-20-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-(2,2,2-trifluoro-1-hydroxyethyl)phenol is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals for its ability to contribute to the development of new and effective compounds.
Used in Organic Compounds Synthesis:
This chemical is utilized as a building block in the production of specialty chemicals, playing a crucial role in the creation of complex organic molecules with specific properties.
Used in Organic Synthesis as a Reagent:
4-(2,2,2-trifluoro-1-hydroxyethyl)phenol is employed as a reagent in organic synthesis, facilitating various chemical reactions and contributing to the formation of desired products.
Used in Paints, Adhesives, and Coatings Industry:
4-(2,2,2-trifluoro-1-hydroxyethyl)phenol is used as a solubilizer, emulsifier, or dispersant in formulations for paints, adhesives, and coatings, enhancing the performance and properties of these materials.
It is essential to handle 4-(2,2,2-trifluoro-1-hydroxyethyl)phenol with care and adhere to safety guidelines due to its potential health and environmental hazards, ensuring the safe and effective use of this versatile chemical compound in various applications.

Upstream product

• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 108-95-2 phenol 
• 55605-84-0 trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 1279691-46-1 4-[1-(5-dimethylamino-naphthalene-1-sulfonyloxy)-2,2,2-trifluoro-ethyl]-phenyl acetate 
• 60-24-2 2-hydroxyethanethiol 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 25244-30-8 4-(allyloxy)bromobenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 403648-66-8 (±)-trimethyl-2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxysilane 
• 1823-63-8 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one 

Downstream Products

• 1823-63-8 2,2,2-trifluoro-1-(4-hydroxyphenyl)ethan-1-one 
• 1429029-75-3 4-(1-hydroxy-2,2,2-trifluoroethyl)cyclohexanol 
• 86571-21-3 4-(2,2,2-trifluoroethyl)phenol 
• 440659-02-9 4-(1-chloro-2,2,2-trifluoroethyl)phenol 
• 635752-84-0 2-(benzhydrylidene-amino)-4,4,4-trifluoro-3-(4-hydroxy-phenyl)-butyric acid ethyl ester 
• 635752-86-2 4,4,4-trifluoro-3-(4-hydroxy-phenyl)-2-nitro-butyric acid ethyl ester 

Relevant academic research and scientific papers

Convenient synthesis of α-trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl α-trifluoroacetaldehyde hemiaminal

Aminofluoroalkylation of various heteroarenes or substituted benzenes with the N-trimethylsilyl hemiaminals, prepared from 1,1,1,3,3,3-hexamethyldisilazane and gaseous trifluoroacetaldehyde, smoothly underwent at room temperature in the presence of a Lewis acid. [(1-Aryl-2,2,2-trifluoro)ethyl]amines or bis[(1-aryl-2,2,2-trifluoro)ethyl]amines were afforded in moderate to high yields.

Synthesis and synthetic applications of (4-hydroxyphenyl)perfluoroalkylmethanols

Development of the convenient method for the synthesis of (hydroxyphenyl)perfluoro-alkylmethanols was achieved by the Meerwein-Ponndorf-Verley (MPV) type reduction of the in situ-generated perfluoroalkylated ketones as the key step. The benzylic OH group of the resultant alcohols was successfully converted to H or Rf(CH2)nO by way of the corresponding chlorides, this transformation being not easy by any other methods.

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

Design and application of esterase-labile sulfonate protecting groups

Three esterase-labile, but chemically-stable sulfonate protecting groups have been designed and synthesized. One of these sulfonate esters allowed the cytoplasmic delivery and unmasking of a sulfonated dye in live cells.

BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula (I), or compositions including them, to a subject. The invention also comprises further embodiments of Formulas (II) and (III), intermediates and processes useful for the preparation of compounds of the invention.

Regioselective substitution of phenols with trifluoroacetaldehyde ethyl hemiacetal

2,2,2-Trifluoroethanols are of great interest because of their unique physical, chemical, and biological properties. Trifluoroacetaldehyde is a very efficient reagent for obtaining 2,2,2-trifluoroethanols. Because it is unavailable commercially, its hemia

Substituted cyclohexylaminopyrimidines

Compounds of formula I where R1is hydrogen, chlorine, fluorine or methyl, R2and R3, which may be the same or different from each other, are hydrogen, halogen, cyano, (C1-C4)-alkyl, vinyl, ethynyl, (C

Nucleophilic trifluoromethylation and difluorination of substituted aromatic aldehydes with Ruppert's and Deoxofluor? reagents

Efficient, high yield syntheses of 2,2,2-trifluoro-1-(N,N-dialkylaminophenyl)-ethanols (3a, b) and 2,2,2-trifluoro-1-(hydroxyaryl)ethanols (6c-g) by reacting Ruppert's reagent, (trifluoromethyl)trimethylsilane (TMSCF3), with appropriate substra

Electrochemical oxidation of 2,2,2-trifluoroethanol to trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal

Electrochemical oxidation of 2,2,2-trifluoroethanol (1) gave trifluoroacetaldehyde 2,2,2-trifluoroethyl hemiacetal (2b), which was more reactive than commercially available trifluoroacetaldehyde ethyl hemi-acetal (2a). The high reactivity of 2b was utiliz

Facile substitution of N,N-dimethylanilines and phenols with trifluoroacetaldehyde ethyl hemiacetal

2,2,2-Trifluoro-1-(N,N-dimethylaminophenyl)ethanols were easily formed in excellent yields by electrophilic substitution between N,N- dimethylanilines 1a, b and trifluoroacetaldehyde ethyl hemiacetal (TFAE). The corresponding substitution of phenols 2a-e