440659-07-4

Upstream product

• 168130-83-4 4-(1-hydroxy-2,2,2-trifluoroethyl)-2-methoxy-phenol 

Downstream Products

• 635753-08-1 2-methoxy-4-(2,2,2-trifluoro-1-nitromethyl-ethyl)phenol 
• 635752-89-5 4,4,4-trifluoro-3-(4-hydroxy-3-methoxy-phenyl)-2-nitro-butyric acid ethyl ester 

Relevant academic research and scientific papers

Nucleophilic replacement of p-(1-chloro-2,2,2-trifluoroethyl)phenols: Novel synthesis of β-trifluoromethyl-tyrosine

Three para -(1-chloro-2,2,2-trifluoroethyl)phenols 2a-c were prepared by selective α-chlorination of the corresponding alcohols 1a-c. Substitution of 2a by active methylene compound 4 proceeds smoothly in the presence of an appropriate base at room temper

Facile synthesis of o- and p-(1-trifluoromethyl)-alkylated phenols via generation and reaction of quinone methides

Several ortho- and para-(1-chloro-2,2,2-trifluoroethyl) phenols were prepared from the corresponding alcohols and thionyl chloride in the presence of pyridine. They reacted smoothly with sodium borohydride and Grignard reagents under mild conditions, forming 2,2,2-trifluoroethyl- or 1-trifluoromethylalkylphenols in high yields.