635753-08-1

Upstream product

• 75-52-5 nitromethane 
• 440659-07-4 4-(1-chloro-2,2,2-trifluoroethyl)-2-methoxy-phenol 
• 168130-83-4 4-(1-hydroxy-2,2,2-trifluoroethyl)-2-methoxy-phenol 

Relevant academic research and scientific papers

Nucleophilic replacement of p-(1-chloro-2,2,2-trifluoroethyl)phenols: Novel synthesis of β-trifluoromethyl-tyrosine

Three para -(1-chloro-2,2,2-trifluoroethyl)phenols 2a-c were prepared by selective α-chlorination of the corresponding alcohols 1a-c. Substitution of 2a by active methylene compound 4 proceeds smoothly in the presence of an appropriate base at room temper