440676-95-9Relevant academic research and scientific papers
Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to L-Thyronine
Stanton, James L.,Cahill, Edna,Dotson, Ronald,Tan, Jenny,Tomaselli, Hollis C.,Wasvary, Jong M.,Stephan, Zouhair F.,Steele, Ronald E.
, p. 1661 - 1663 (2000)
The synthesis of substituted phenoxyphenyl oxamic acid derivatives related to L-thyronine (L-T3) is described. The in vitro and in vivo cholesterol lowering and cardiovascular effects of these compounds are presented and discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.
COMPOUNDS FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE
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Page/Page column 53, (2019/11/19)
Disclosed are compounds that can modulate DDAH and the amount of asymmetric dimethylarginine (ADMA) in a subject. Also provided are pharmaceutical compositions comprising these compounds, as well as methods of using these compositions to treat and/or prevent diseases associated with elevated or low levels of DDAH and ADMA.
A straightforward hetero-diels-alder approach to (2-ambo,4′R, 8′R)-α/β/γ/δ-4-thiatocopherol
Menichetti, Stefano,Amorati, Riccardo,Bartolozzi, Maria Grazia,Pedulli, Gian Franco,Salvini, Antonella,Viglianisi, Caterina
supporting information; experimental part, p. 2218 - 2225 (2010/07/03)
A simple and original inverse electron demand hetero-Diels-Alder reaction has been successfully applied to the synthesis of (2-ambo,4′R,8′R)- α/β/γ/δ-4-thiatocopherol. Commercially available methyl hydroquinones and. (2E,7R,11R)-(+)-phytol were exploited for the preparation of the ortho-thioquinones, acting as electron-poor dienes, and of the proper 1,3-diene used as dienophile, respectively. The benzoxathiine cycloadducts, with the required tocopherol-like skeleton, were obtained with complete control, of regio and chemoselectivity. The antioxidant activity of 4-thiatocopherols was measured and rationalized in comparison with that of the corresponding natural components of Vitamin E.
