14786-82-4

Basic information

• Product Name: 4-methoxy-3-methyl-phenol
• Synonyms: 4-methoxy-3-methyl-phenol;Phenol, 4-Methoxy-3-Methyl-;methoxy-3-methyl-phenol
• CAS NO: 14786-82-4
• Molecular Formula: C₈H₁₀O₂
• Molecular Weight: 138.1638
• Mol File: 14786-82-4.mol
• Article Data: 27

Chemical Properties

• Melting Point: 44-45 °C
• Boiling Point: 244.7 °C at 760 mmHg
• Flash Point: 121.9 °C
• Appearance: /
• Density: 1.078 g/cm³
• Vapor Pressure: 0.0191mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: 2-8°C
• PKA: 10.56±0.18(Predicted)
• CAS DataBase Reference: 4-methoxy-3-methyl-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-3-methyl-phenol(14786-82-4)
• EPA Substance Registry System: 4-methoxy-3-methyl-phenol(14786-82-4)

Safety Data

• Hazardous Substances Data: 14786-82-4(Hazardous Substances Data)

Usage

General Description

4-methoxy-3-methylphenol, also known as guaiacol, is an aromatic organic compound that contains a methoxy group (O-CH3) and a methyl group (CH3) attached to a benzene ring. It is commonly found in wood smoke, and it has a distinctive smoky, medicinal odor. Guaiacol is used in the production of various chemicals and pharmaceuticals, including as a precursor for the synthesis of vanillin, a popular flavoring agent. In addition, it has been studied for its potential antioxidant and anti-inflammatory properties. Guaiacol is also used in the food industry as a preservative and flavoring agent, particularly in the production of smoked meats and cheeses. Overall, 4-methoxy-3-methylphenol has various industrial applications and potential uses in the medical and food industries.

InChI:InChI=1/C8H10O2/c1-6-5-7(9)3-4-8(6)10-2/h3-5,9H,1-2H3

Upstream product

• 578-58-5 2-methylmethoxybenzene 
• 90-05-1 2-methoxy-phenol 
• 175883-62-2 4-methoxy-3-methylphenylboronic acid 
• 67-56-1 methanol 
• 108-39-4 3-methyl-phenol 
• 32723-67-4 3-methyl-4-anisaldehyde 
• 553-97-9 2-Methyl-1,4-benzoquinone 
• 71528-84-2 4-hydroxy-3-methylphenyl benzoate 
• 620-25-7 N-(3-methylphenyl)hydroxylamine 
• 440676-95-9 4-((tert-butyldimethylsilyl)oxy)-2-methylphenol 
• 95-71-6 2-methylbenzene-1,4-diol 
• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 14804-31-0 2-methyl-4-bromoanisole 
• 24599-58-4 2,5-dimethoxy toluene 

Downstream Products

• 75714-41-9 2-(4-Methoxy-3-methylphenoxy)ethanol 
• 13523-09-6 4-Methoxy-5-methyl-1,2-benzochinon 
• 13523-07-4 6-bromo-4-methoxy-3-methylphenol 
• 954096-64-1 C₁₇H₂₂O₄ 
• 954096-59-4 C₁₆H₂₀O₄ 
• 954096-61-8 C₁₇H₂₄O₅ 
• 954096-62-9 C₁₈H₂₆O₇S 
• 13052-34-1 4-methoxy-5-methyl-2-(1-methyl-2-propen-1-yl)phenol 
• 1174528-02-9 C₂₀H₂₁NO₅ 
• 136-90-3 4-methoxy-3-methylaniline 
• 125708-82-9 1-methoxy-2-methyl-4-nitrosobenzene 

Relevant articles and documents

Towards the rational design of novel charge-transfer materials: Biaryls with a dihedral angle-independent hole delocalization mechanism

Biaryl cation radicals are important electroactive materials, which show two mechanisms of hole delocalization: static delocalization at small interplanar dihedral angles and dynamic hopping at larger angles, reflecting the interplay between electronic coupling and structural reorganization. Herein, we describe the rational design of biaryls possessing an invariant hole delocalization mechanism.

Fabricating Bifunctional Co?Al2O3@USY Catalyst via In-Situ Growth Method for Mild Hydrodeoxygenation of Lignin to Naphthenes

To enhance the catalytic activity and stability of metal catalysts in the hydrodeoxygenation of lignin derivatives into naphthenes, a bifunctional Co?Al2O3@USY catalyst was fabricated by the reduction of CoAl layered double hydroxide in-situ grown on the USY zeolite. In the hydrodeoxygenation of guaiacol, a 100.0 % conversion with cyclohexane yield up to 93.6 % was achieved at 180 °C, 3 MPa for 4 h, which should be the hitherto lowest reaction temperature that has been reported over Co-based metal catalysts. This catalyst was also relatively stable with 5 runs and exhibited excellent catalytic performance in the hydrodeoxygenation of other lignin model compounds and even real lignin feedstock into naphthenes. The high-efficiency of Co?Al2O3@USY was attributed to the synergistic effect between well-dispersed small Co nanoparticles and abundant acidic sites on the USY surface, while the outstanding stability was attributed to the anchoring effect of Al2O3 matrix to Co nanoparticles which avoided the leaching of Co species and particle agglomeration. This work provides a potential strategy for the design of an efficient and stable catalyst for lignin utilization.

Para -Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

Palladium/Norbornene-Catalyzed Indenone Synthesis from Simple Aryl Iodides: Concise Syntheses of Pauciflorol F and Acredinone A

To show the synthetic utility of palladium/norbornene (Pd/NBE) cooperative catalysis, here we report concise syntheses of indenone-based natural products, pauciflorol F and acredinone A, which are enabled by direct annulation between aryl iodides and unsa