441295-89-2

Upstream product

• 34403-48-0 methyl-4-cyanobenzylamine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 633698-74-5 2-[4-(2,8-dimethyl-3,9-dioxo-11-phenyl-5,10-dioxa-2,8-diazaundec-1-yl)phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633698-75-6 4,5-dihydro-2-[4-[[methyl[[2-(methylamino)ethoxy]acetyl]amino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633698-77-8 4,5-dihydro-2-[4-[[[[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633698-76-7 4,5-dihydro-2-[4-[[methyl[[2-[methyl[[2-(trifluoromethyl)phenyl]sulfonyl]amino]ethoxy]acetyl]amino]methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633698-83-6 2-[4-[[[[2-[[(2-cyanophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633698-85-8 2-[4-[[[[2-[[(3-chloro-2-methylphenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633698-88-1 2-[4-[[[[2-[[(2,6-difluorophenyl)sulfonyl]methylamino]ethoxy]acetyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633696-58-9 2-[4-[[[5-[[(2,4-dichloro-3-methylphenyl)sulfonyl]methylamino]-1-oxopentyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 441295-92-7 4,5-dihydro-2-[4-[(methylamino)methyl]phenyl]-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633696-67-0 2-[4-[[[4-[[(2,4-dichloro-3-methylphenyl)sulfonyl]methylamino]-1-oxobutyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633696-68-1 2-[4-[[[3-[[(2,4-dichloro-3-methylphenyl)sulfonyl]methylamino]-1-oxopropyl]methylamino]methyl]phenyl]-4,5-dihydro-1-H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 
• 633696-69-2 2-[4-[[[(2E)-4-[[(2,4-dichloro-3-methylphenyl)sulfonyl]methylamino]-1-oxo-2-butenyl]methylamino]methyl]phenyl]-4,5-dihydro-1H-imidazole-1-carboxylic acid 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists

The bradykinin (BK) B1 receptor is an attractive target for the treatment of chronic pain and inflammation. Starting from a dual B1 and B2 antagonist, novel antagonists were designed that display low-nanomolar affinity for human B1 receptor and selectivity over B2. Initially, potent imidazoline derivatives were studied, but these compounds suffered from low bioavailability. This issue could be overcome by the use of less basic amino derivatives leading to orally active compounds.

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Novel arylsulphonamide derivatives and use thereof as therapeutic agents

The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use.