502609-87-2Relevant academic research and scientific papers
REVERSE HYDROXAMIC ACID DERIVATIVES
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Page 56, (2008/06/13)
Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): (wherein A is a hydrogen atom or the like; Ar1 is an arylene or the like; Ar2 is an optionally substituted aryl, a heteroaryl or the
Reverse hydroxamate-based selective TACE inhibitors
Kamei, Noriyuki,Tanaka, Tomohiro,Kawai, Kentaro,Miyawaki, Kyosei,Okuyama, Akihiko,Murakami, Yoshiko,Arakawa, Yoshio,Haino, Makoto,Harada, Tatsuhiro,Shimano, Masanao
, p. 2897 - 2900 (2007/10/03)
Reverse hydroxamate-based selective TACE inhibitors are described. They have potent TACE inhibitory activities and excellent selectivities against MMP-1, 2, 3, 8, 9, 13, 14, and 17. One representative compound, 18 has demonstrated an excellent oral inhibitory activity of the lipopolysaccharide (LPS)-stimulated TNF-α production in rats.
