4413-42-7

Upstream product

• 768323-53-1 N-[(2-chloro-phenoxy)-acetyl]-hydrazinecarbodithioic acid 
• 36304-40-2 (2-chlorophenoxy)acetic acid hydrazide 
• 52094-97-0 ethyl 2-(2-chlorophenoxy)acetate 
• 95-57-8 2-monochlorophenol 
• 614-61-9 (2-chlorophenoxy)acetic acid 
• 2231-57-4 Thiocarbohydrazide 

Downstream Products

• 14758-90-8 5-(2-Chloro-phenoxymethyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-amino}-4H-[1,2,4]triazole-3-thiol 
• 623936-90-3 5-(2-Chloro-phenoxymethyl)-4-{[1-[5-(4-methoxy-2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazole-3-thione 
• 682769-41-1 3-[4-amino-5-(2-chloro-phenoxymethyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-3-(5-nitro-furan-2-yl)-1-phenyl-propenone 
• 682769-49-9 3-[4-amino-5-(2-chloro-phenoxymethyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-3-(5-nitro-furan-2-yl)-1-p-tolyl-propenone 

Relevant academic research and scientific papers

Synthesis and?studies on?some?new fluorine containing triazolothiadiazines as?possible antibacterial, antifungal and?anticancer agents

Synthesis of a series of 7-arylidene-6-(2,4-dichlorophenyl)-3-aryloxymethyl/anilinomethyl-1,2,4-t riazolo[3,4-b]-1,3,4-thiadiazines (3) by the condensation of 3-aryl-1-(2,4-dichloro-5-fluorophenyl)-2-bromo-propen-1-one (1) and 4-amino-5-mercapto-3-aryloxy

Synthesis of some new 1,2,4-triazolo[3,4-b]-thiadiazole derivatives as possible anticancer agents

3-Substituted-4-amino-5-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Their cyclization with carboxylic acids gives fused five-membered derivatives, whereas with α-bromoketones gives a six-membered heterocycle. In this article we report the synthesis of a series of 1,2,4-triazolo[3,4-b]thiadiazoles 5 starting from 4-amino-3-substituted-5-mercapto-1,2,4-triazoles 3 and fluorobenzoic acids 4 using phosphorous oxychloride as cyclizing agent. Fourteen of the newly synthesized compounds were screened for anticancer properties. Four among them showed in vitro anticancer activity.

Synthesis and antibacterial activity of N-bridged heterocycles derived from aryloxymethyltriazoles

Reactions of 3-aryloxymethyl-4-amino-5-mercapto-1,2,4-triazoles 1 with aromatic carboxylic acids, furoic acid, oxalic acid, monochloroacetic acid and phenacyl bromide furnish various N-bridged heterocycles viz., triazolothiadiazoles, bistriazolothiadiazoles, triazolothiadiazinones and triazolothiadiazines. The structures of these N-bridged heterocycles are characterized on the basis of elemental analyses, IR, NMR and mass spectral data. Some of these compounds are also subjected to antibacterial screening studies.

Synthesis of Some Substituted 4-(5-Nitro-2-furfurylideneamino)-5-mercapto-1,2,4-triazoles and 7H-6-(5-Nitro-2-furyl)-s-triazolothiadiazines

Seven 4-amino-3-aryloxymethyl-5-mercapto-1,2,4-triazoles (1a-g) have been synthesized and converted into 3-aryloxymethyl-4-(5-nitro-2-furfurylideneamino)-5-mercapto-1,2,4-triazoles (2a-g) and 7H-3-aryloxymethyl-6-(5-nitro-2-furyl)-s-triazolothiadiazines (3a-g).Most of the compounds of series 2 and 3 have been found to be active against both gram positive and gram negative bacteria at less than 5μg ml concentration.