441304-12-7

Upstream product

• 140-89-6 potassium ethyl xanthogenate 
• 201676-71-3 5,6-dimethyl-2-methoxy-3-amino-pyridine 
• 98276-88-1 3-nitro-5,6-dimethyl-2(1H)-pyridinone 
• 72716-80-4 1,2-dihydro-5,6-dimethyl-2-oxo-3-pyridinecarbonitrile 
• 132247-74-6 (E)-4-hydroxy-3-methylbut-3-en-2-one sodium salt 
• 65213-96-9 2,3-dimethyl-6-chloro-5-nitropyridine 
• 27992-31-0 5,6-dimethyl-2(1H)-pyridone 

Relevant academic research and scientific papers

ANTIPRURITICS

It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having an agonistic activity to the cannabinoid receptor shows an antipruritics effect.

PYRIDONE DERIVATIVE HAVING AFFINITY FOR CANNABINOID 2-TYPE RECEPTOR

It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R' is a group represented by the formula: -Y1-Y2-Y3Ra wherein Y1 is single bond or the like; Y2 is -C(=O)-NH- or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.