27992-31-0

Usage

Uses

Used in Pharmaceutical Industry:
5,6-DIMETHYL-1H-PYRIDIN-2-ONE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5,6-DIMETHYL-1H-PYRIDIN-2-ONE is utilized as a precursor in the production of agrochemicals. Its role in this industry is pivotal for the synthesis of compounds that can be used in pest control and crop protection, thereby supporting agricultural productivity.
Used in Specialty Chemicals Production:
5,6-DIMETHYL-1H-PYRIDIN-2-ONE is also used as a building block in the synthesis of specialty chemicals. Its versatility enables its application across a broad spectrum of chemical products, catering to specific industry needs and enhancing the performance of final products.
Overall, 5,6-DIMETHYL-1H-PYRIDIN-2-ONE's applications cut across multiple industries, highlighting its importance as a chemical intermediate with potential for further exploration and utilization in various chemical processes.

InChI:InChI=1/C7H9NO/c1-5-3-4-7(9)8-6(5)2/h3-4H,1-2H3,(H,8,9)

Upstream product

• 72716-80-4 2-hydroxy-5,6-dimethylnicotinonitrile 
• 51727-05-0 5,6-dimethyl-2-hydroxynicotinic acid 
• 58483-99-1 2-amino-5,6-dimethyl-nicotinamide 
• 132247-74-6 (E)-4-hydroxy-3-methylbut-3-en-2-one sodium salt 
• 10413-01-1 4-methyl-5-oxo-hexanenitrile 
• 72716-80-4 1,2-dihydro-5,6-dimethyl-2-oxo-3-pyridinecarbonitrile 
• 52648-22-3 3,4-dihydro-5,6-dimethyl-2(1H)-pyridone 
• 90007-21-9 2-hydroxy-5,6-dimethyl-nicotinic acid amide 
• 22428-91-7 2-methyl-3-oxobutanal 

Downstream Products

• 99934-42-6 2,3-Dimethyl-6-phenoxy-pyridine 
• 99934-33-5 (1S,8R)-8,12-Dimethyl-9-aza-tricyclo[6.2.2.0^2,7]dodeca-2⁽⁷⁾,3,5,11-tetraen-10-one 
• 441304-12-7 5,6-dimethyl-3-[[ethoxy(thiocarbonyl)]thio]-2-methoxypyridine 
• 65213-96-9 2,3-dimethyl-6-chloro-5-nitropyridine 
• 858338-82-6 N-[4-(3,5-dimethyl-benzyl)-2-methoxy-5,6-dimethyl-pyridin-3-yl]-2,2-dimethyl-propionamide 
• 847741-02-0 N-[2-methoxy-5,6-dimethyl-4-(3-methylbenzoyl)pyridin-3-yl]-2,2-dimethylpropionamide 
• 847741-01-9 N-[4-((3-methylphenyl)hydroxymethyl)-2-methoxy-5,6-dimethylpyridin-3-yl]-2,2-dimethylpropionamide 
• 248247-23-6 3-amino-4-(3,5-dimethyl-benzyl)-5,6-dimethyl-1H-pyridin-2-one 
• 248247-85-0 3-amino-5,6-dimethyl-4-(3-methylbenzoyl)pyridin-2(1H)-one 
• 80675-99-6 exo-N-phenyl-3,4,8-trimethyl-8-aza-7-oxobicyclo<2.2.2>oct-4-ene-1,2-dicarboximide 
• 98276-88-1 3-nitro-5,6-dimethyl-2(1H)-pyridinone 
• 583-61-9 2,3-Lutidine 

Relevant academic research and scientific papers

PYRIDINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR TREATING DISEASES RELATED TO MCH RECEPTOR

The present invention encompasses novel substituted pyridine compounds of Formula (I), which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: In vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains

In a program to optimize the anti-HIV activity of the 4-benzyl and 4-benzoyl-3-dimethylaminopyridinones 9 and 10, lead compounds in a new class of highly potent non-nucleoside type inhibitors of HIV-1 reverse transcriptase, modification of the alkyl substitutents at the C-5 and C-6 positions on the pyridinone ring and of the substitutents on the C-3 amino group has been studied. Of the 17 new 5/6-modified analogues prepared, compounds 31b and 32b substituted at C-5 by an extended nonpolar chain containing an ether function and a C-6 methyl group and compound 35 bearing a C-5 ethyl/C-6 hydroxymethyl substituent pattern were selected on the basis of their in vitro activity against wild-type HIV and the three principle mutant strains, K103N, Y181C, and Y188L. When tested further, it was shown that these molecules, and in particular compound 35, are globally more active than 9, 10, and efavirenz against an additional eight single [L100I, K101E, V106A, E138K, V179E, G190A/S, and F227C] and four double HIV mutant strains [L100I + K103N, K101E + K103N, K103N + Y181C, and F227L + V106A], which are clinically relevant. Concerning modulation of the N-3 substituent, 36 new analogues were prepared. Of these, the N-methyl-N-(2-methoxyethyl)-substituted compounds 40, 42, and 62, as well as the doubly modified compounds 77a and 77b, were selected from the initial screen and were subsequently shown to be active at sub-micromolar concentrations (IC50's) against all the other mutant strains except K103N + Y181C and F227L + V106A. Two possible, but distinct, modes of binding of these analogues in RT were suggested from molecular modeling studies. The preferred mode of binding for compound 62, corresponding to the predicted "orientation 1", was revealed in the X-ray crystal structure of the compound 62-RT complex.

ANTIPRURITICS

It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having an agonistic activity to the cannabinoid receptor shows an antipruritics effect.

PYRIDONE DERIVATIVE HAVING AFFINITY FOR CANNABINOID 2-TYPE RECEPTOR

It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R' is a group represented by the formula: -Y1-Y2-Y3Ra wherein Y1 is single bond or the like; Y2 is -C(=O)-NH- or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.

Preparation and Reaction of Pyridones: Steric and Electronic Effects on Cycloadditions with 2(1H)-Pyridones

The reactions of series of substituted 2(1H)-pyridones with dimethyl butynedioate have been studied.Cycloadditions across the 3,6-positions can be observed in certain instances and are particularly favoured where steric buttressing occurs between the substituent groups of the starting pyridones.The pyridone could not be induced to react with simple olefins, either by intermolecular or, via incorporation of alkenyl substituents, by intramolecular processes.From the results it is shown that 2-pyridones can be encouraged to behave as reactive classical dienes in cycloaddition reactions.