4414-81-7

Usage

Uses

Used in Pharmaceutical Industry:
3-(3-METHYL-1H-INDOL-1-YL)PROPANENITRILE is used as a precursor and intermediate for the synthesis of various pharmaceuticals and organic compounds. Its unique properties and indole core make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Organic Chemistry:
3-(3-METHYL-1H-INDOL-1-YL)PROPANENITRILE is used as a building block in organic chemistry for the creation of complex molecules. Its nitrile functional group and methyl substitution at the 3-position of the indole ring provide versatility in the synthesis of a wide range of organic compounds.

InChI:InChI=1/C12H12N2/c1-10-9-14(8-4-7-13)12-6-3-2-5-11(10)12/h2-3,5-6,9H,4,8H2,1H3

Upstream product

• 83-34-1 3-Methylindole 
• 107-13-1 acrylonitrile 
• 2417-90-5 bromopropionitrile 

Downstream Products

• 57662-47-2 3-(3-methylindol-1-yl)propanoic acid 
• 138653-39-1 11-Methyl-1-phenyl-4,5-dihydro-3H-[1,4]diazepino[1,2-a]indole 

Relevant academic research and scientific papers

INHIBITORS FOR THE Β-CATENIN / T-CELL FACTOR PROTEIN–PROTEIN INTERACTION

Disclosed are inhibitors for the β-catenin/T-cell factor interaction. The inhibitors are selective for β-catenin/T-cell factor over β-catenin/cadherin and β-catenin/APC interactions. Methods of using the disclosed compounds to treat cancer are also disclosed.

Acylation, cyanoethylation and alkylation of methyl and phenyl indolylmagnesium salts: Influence of the substituents on the C- and N- reaction products

Analysis of the influence of the substitution on indolylmagnesium salts in the reaction with benzoyl chloride, acrylonitrile and methyl iodide, giving the C- and N-derivatives, have been carried out. The yield in the C- and N-product depends upon the electronic character and position of the substituent (methyl or phenyl) on the indole ring and of the ethereal solvent as well as the concentration and molar ratio of the reagents. The 2- or 3- phenyl substituted indolylmagnesium salts with acrylonitrile always gave the 1-(2-cyanoethyl)indole derivative.

Highly potent inhibitors of the Grb2-SH2 domain

Highly potent inhibitors of the Grb2-SH2 domain have been synthesized. They share the common sequence: Ac-Pmp-Ac6c-Asn-NH-(3-indolyl-propyl). Different substituents at the 3-indolyl-propylamine C-terminal group were explored to further improve the activity. This is the first example of inhibitors of SH2 domains with sub-nanomolar affinity reported to date.