4414-86-2

Usage

Uses

Used in Pharmaceutical Industry:
MPAB is used as a building block in the synthesis of pharmaceuticals due to its versatile reactivity and potential biological activity. It can be employed in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
MPAB is also used as a building block in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals.
Used as a Reagent in Organic Synthesis:
MPAB can be used as a reagent in organic synthesis, facilitating various chemical reactions and the formation of new compounds.
Used as a Research Tool in Medicinal Chemistry:
MPAB serves as a research tool in medicinal chemistry, aiding scientists in understanding the structure-activity relationships of various compounds and guiding the design of new pharmaceutical agents.

Upstream product

• 13534-99-1 2-Amino-3-bromopyridine 
• 504-29-0 2-aminopyridine 
• 7546-48-7 N,N-dimethyl-1-(2-methyl-1H-pyrrolo[2,3-b] pyridin-3-yl)methanamine 
• 933717-06-7 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 
• 773837-37-9 sodium cyanide 
• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 872365-14-5 2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid 

Relevant academic research and scientific papers

Design, synthesis, and spectroscopic study of 7-azaindolyl hydrazones with anti-breast cancer activity

A series of 7-azaindolyl hydrazones were prepared by reacting of hydrazides of 7-azaindole-3-acetic acids with aromatic aldehydes and N-substituted indolyl-3-carboxyaldehydes. Structure of all the synthesized compounds were satisfactorily correlated by IR, 1H NMR, 13C NMR and mass spectroscopic evidences. The synthesized compounds were evaluated for their possible anticancer potential against MCF-7 induced breast carcinoma. It is worth mentioning that most of the compounds were considerably active against MCF-7 cell line with GI50 values ranging from 22.3–81.0 μM. The hydrazones of N-1-substituted indole-3-carboxyaldehydes 9f, 9g, 9h, 9c, and 9j were active against MCF-7 cell line with GI50 values less than 40 μM (GI50 = 22.3 and 24.9, 29.6, 30.2 and 37.8 μM respectively) with moderate TGI values (TGI = 56.6, 59.5, 65.5, 70.7 and 94.6 μM respectively). The active compounds were also screened against the normal Vero monkey cell line, which showed moderate selectivity against inhibition of cancer cells.

PREPARATION OF 2-[2-METHYL-1-[[4-METHYLSULFONYL-2-(TRIFLUORO METHYL)PHENYL]METHYL] PYRROLO[2,3-B]PYRIDIN-3-YL]ACETIC ACID

The present invention relates to a novel compound of Formula IV and use of said compound for the preparation of 2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl] methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid [fevipiprant], Formula IV wherein A is SO2Me, halogen or a leaving group. The present invention further relates to a process of preparation of pharmaceutical acceptable salts of fevipiprant and composition thereof.

Fevipiprant selective prostaglandin DP2 (CRTh2) inhibitor treatment of asthma

Prostaglandin D2 (PGD2), a major prostanoid, releases from activated mast cells. It activates and recruits various inflammatory cells like eosinophils and basophils through DP2 receptors to the site of inflammation and further promotes late-phase allergic reactions. For the last decade, the scientific community has extensively explored this pathway and synthesized various specific DP2 receptor antagonists for the management of asthma. About 20 compounds with DP2 antagonistic activity have reached different stages of clinical development. Among these, fevipiprant is one of the most advanced oral DP2 inhibitors as it selectively blocks the DP2 receptors. Fevipiprant has demonstrated an acceptable safety profile in phase II studies as evident from significant reduction of moderate to severe asthma exacerbations. Currently this novel antiasthmatic drug is in phase III clinical trials. This review provides a brief overview of PGD2 blockers, particularly fevipiprant and its preclinical pharmacology and clinical development, by providing a summary of completed or ongoing clinical studies assessing its safety and efficacy in asthma.

ACTIVE COMPOUNDS

Therapeutically active compounds of the formula: wherein the variables are defined in the specification are provided