4416-66-4

Basic information

• Product Name: Phenol, 2-fluoro-, 4-methylbenzenesulfonate
• Synonyms: o-Fluorphenyltosylat
• CAS NO: 4416-66-4
• Molecular Formula: C13H11FO3S
• Molecular Weight: 266.293
• Mol File: 4416-66-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 2-fluoro-, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-fluoro-, 4-methylbenzenesulfonate(4416-66-4)
• EPA Substance Registry System: Phenol, 2-fluoro-, 4-methylbenzenesulfonate(4416-66-4)

Safety Data

• Hazardous Substances Data: 4416-66-4(Hazardous Substances Data)

Upstream product

• 367-12-4 2-fluorophenol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 445-29-4 o-fluoro-benzoic acid 
• 388-82-9 2,2'-difluorobiphenyl 
• 367-12-4 2-fluorophenol 
• 104-15-4 toluene-4-sulfonic acid 

Relevant articles and documents

Direct Carboxylation of Aryl Tosylates by CO2 Catalyzed by in situ-Generated Ni0

A novel Ni0-catalyzed carboxylation of aryl tosylates with carbon dioxide has been achieved under moderate temperatures and atmospheric pressure. In this procedure, the active Ni0 species is generated in situ by simply mixing the Ni0 precatalyst [NiBr2(bipy)] with an excess of manganese metal. This approach requires neither a glove-box nor the tedious preparation of sophisticated intermediate organometallic derivatives. This mild, convenient, and user-friendly process is successfully applied to the valorization of carbon dioxide and the synthesis of versatile reactants with broad tolerance of substituents.

Copper-catalysed coupling of aryl tosylates with sodium arylsulfinates

Diaryl sulfones derivatives were easily synthesised from aryl tosylates and sodium arylsulfinates in high yields using [Cu(CH3CN)4]PF6 as catalyst. The transformation is efficient, simple and the starting materials are readily available.