441715-34-0

Basic information

• Product Name: 1H-Indole,4-fluoro-1-methyl-(9CI)
• Synonyms: 1H-Indole,4-fluoro-1-methyl-(9CI);1H-Indole, 4-fluoro-1-methyl-
• CAS NO: 441715-34-0
• Molecular Formula: C9H8FN
• Molecular Weight: 149.167
• Product Categories: HALIDE;AMINETERTIARY
• Mol File: 441715-34-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole,4-fluoro-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole,4-fluoro-1-methyl-(9CI)(441715-34-0)
• EPA Substance Registry System: 1H-Indole,4-fluoro-1-methyl-(9CI)(441715-34-0)

Safety Data

• Hazardous Substances Data: 441715-34-0(Hazardous Substances Data)

Usage

Derivative of indole

Heterocyclic aromatic organic compound

Fluorine atom

Attached to the indole ring

Methyl group

Attached to the indole ring

Use in pharmaceutical industry

Synthesis of various drugs

Potential applications

Organic chemistry and drug discovery

Interesting target for research and development

Due to the presence of the fluorine atom and the methyl group

Upstream product

• 387-43-9 4-fluoroindole 
• 333-27-7 methyl trifluoromethanesulfonate 
• 74-88-4 methyl iodide 

Downstream Products

• 912331-36-3 boronic acid, 4-fluoro-1-methyl-indol-2-yl 

Relevant articles and documents

Cobalt-Catalyzed Enantioselective C–H Arylation of Indoles

Atropoisomeric (hetero)biaryls are scaffolds with increasing importance in the pharmaceutical and agrochemical industries. Although it is the most obvious disconnection to construct such compounds, the direct enantioselective C–H arylation through the concomitant induction of the chiral information remains extremely challenging and uncommon. Herein, the unprecedented earth-abundant 3d-metal-catalyzed atroposelective direct arylation is reported, furnishing rare atropoisomeric C2-arylated indoles. Kinetic studies and DFT computation revealed an uncommon mechanism for this asymmetric transformation, with the oxidative addition being the rate- and enantio-determining step. Excellent stereoselectivities were reached (up to 96% ee), while using an unusual N-heterocyclic carbene ligand bearing an essential remote substituent. Attractive dispersion interactions along with positive C–H-π interactions exerted by the ligand were identified as key factors to guarantee the excellent enantioselection.

Catalytic Aerobic Dehydrogenatin of N-Heterocycles by N-Hydoxyphthalimide

Catalytic methods for the aerobic dehydrogenation of N-heterocycles are reported. In most cases, indoles are accessed efficiently from indolines using catalytic N-hydroxyphthalimide (NHPI) as the sole additive under air. Further studies revealed an improved catalytic system of NHPI and copper for the preparation of other heteroaromatics, for example quinolines. (Figure presented.).

SYK INHIBITOR AND USE METHOD THEREFOR

Provided are a Syk inhibitor and a use method therefor, and in particular, disclosed are quinolinone represented by formula (I) or quinazoline derivatives or pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition, and uses in preparing a medicament for treatment of Syk receptor related diseases.