441787-67-3Relevant academic research and scientific papers
Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists
Zhu, Yun-Fei,Struthers,Connors, Jr., Patrick J.,Gao, Yinghong,Gross, Timothy D.,Saunders, John,Wilcoxen, Keith,Reinhart, Greg J.,Ling, Nicholas,Chen, Chen
, p. 399 - 402 (2007/10/03)
Initial SAR studies on 1-aminomethyl-2-aryl-3-cyano-pyrrolo[1,2-a]pyrimid-7-one-6-carboxylates as human GnRH receptor antagonists were discussed. 2-(2-Methylaminoethyl)pyridine was discovered to be a key feature for generating active compounds. The best compound from the series had 25 nM (Ki) binding affinity to human GnRH receptor.
