442199-17-9 Usage
Chemical structure
A compound consisting of a piperidine ring, a carboxylic acid group, and a 1,1-dimethylethyl ester group, with a 6-methoxy-3-pyridazinyloxy substituent.
Medicinal use
Pirfenidone is used to treat idiopathic pulmonary fibrosis, a chronic lung disease characterized by scarring and thickening of lung tissue.
Mechanism of action
It works as a novel anti-fibrotic agent by reducing the production of fibroblast growth factor and transforming growth factor-beta, which are involved in the formation of fibrous tissue.
Additional therapeutic effects
Pirfenidone also exhibits anti-inflammatory and antioxidant properties, further contributing to its therapeutic effects.
Administration
It is commonly used in combination with other medications to manage symptoms and slow down the progression of idiopathic pulmonary fibrosis.
Route of administration
Pirfenidone is typically administered orally, making it a convenient treatment option for patients.
Efficacy and tolerability
Clinical studies have shown that Pirfenidone is an effective and well-tolerated treatment for idiopathic pulmonary fibrosis, improving patients' quality of life and lung function.
Check Digit Verification of cas no
The CAS Registry Mumber 442199-17-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,2,1,9 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 442199-17:
(8*4)+(7*4)+(6*2)+(5*1)+(4*9)+(3*9)+(2*1)+(1*7)=149
149 % 10 = 9
So 442199-17-9 is a valid CAS Registry Number.
442199-17-9Relevant academic research and scientific papers
Peptide compounds
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, (2008/06/13)
The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.
