4422-34-8

Upstream product

• 181219-01-2 4-pyridineboronic acid pinacol ester 
• 213596-32-8 Trifluoromethanesulfonic acid 4-methoxy-2-nitrophenyl ester 
• 150-76-5 4-methoxy-phenol 
• 1568-70-3 4-methoxy-2-nitrophenol 
• 124252-41-1 (pyridin-4-yl)tributyltin 
• 110-86-1 pyridine 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 158461-62-2 5-Methoxy-2-pyridin-4-yl-phenylamine 
• 159958-43-7 4-(4-hydroxy-2-nitrophenyl)pyridine 
• 158461-94-0 {1-Methyl-2-[2-pyridin-4-yl-5-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 158461-95-1 N-(5-Ethoxy-2-pyridin-4-yl-phenyl)-3-(2,2,2-trifluoro-acetylamino)-butyramide 
• 158461-91-7 [2-(5-Methoxy-2-pyridin-4-yl-phenylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester 
• 158461-35-9 4-[2-Nitro-4-(2,2,2-trifluoro-ethoxy)-phenyl]-pyridine 
• 158461-64-4 2-Pyridin-4-yl-5-(2,2,2-trifluoro-ethoxy)-phenylamine 
• 158461-44-0 4-(4-Ethoxy-2-nitro-phenyl)-pyridine 
• 158461-65-5 5-Ethoxy-2-pyridin-4-yl-phenylamine 

Relevant academic research and scientific papers

Stille and suzuki cross coupling reactions of o-nitrophenyl triflates: A versatile route to a variety of heterocycles

The cross coupling reactions of selected o-nitrophenyl triflates with arylstannane and arylboron substrates are reported. The resultant 2-nitrobiphenyls provide ready access to a variety of substituted heterocycles.

Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative

A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.