4425-71-2

Upstream product

• 486-25-9 9-fluorenone 
• 121-44-8 triethylamine 

Downstream Products

• 4425-73-4 fluoren-9-ylidene-acetic acid 
• 5927-02-6 4,4-Dibrom-1,1-biphenylen-butadien-(1,3) 
• 486-25-9 9-fluorenone 
• 113388-51-5 9-formyl-9-hydroxyfluorene 
• 113388-50-4 Formic acid fluoren-9-ylidenemethyl ester 
• 1569820-57-0 (R)-N-(2-(9H-fluoren-9-ylidene)ethyl)-1-(4-fluorophenyl)ethanamine 
• 1569819-69-7 (R)-N-(2-(9H-fluoren-9-ylidene)ethyl)-1-(4-fluorophenyl)ethanamine 
• 20615-64-9 fluorene-9-carbaldehyde 
• 96378-68-6 trans-1,1-Diphenylen-4-<4-(4-brom-benzolsulfonyl)-phenyl>-butadien-(1,3) 

Relevant academic research and scientific papers

Phase-vanishing method applied to condensation reactions using TiCl4

The phase-vanishing (PV) method using perfluorohexanes as the phase screen was applied to the aldol condensation using TiCl4 as the Lewis acid. A special test tube was used, in which an interface between the fluorous and organic layers was stirred, and cyclohexanone was treated with two equivalents of benzaldehyde derivatives under PV conditions to afford corresponding 2,6-dibenzylidencyclohexanone in good yields. The formyl-methylenation of ketones with triethylamine using TiCl4 was also demonstrated by the PV method.

Metalation of iminium ions formed in the reaction of tertiary amines with TiCl4

(equation presented) TiCl4 reacts with trialkylamines at 0-25°C to give iminium ions that on metalation followed by reaction with diaryl ketones, produce α,β-unsaturated aldehydes.