4425-73-4

Usage

Uses

Used in Organic Synthesis:
9-FLUORENYLIDENEACETIC ACID is used as a key component in organic synthesis for its ability to facilitate the formation of peptide bonds, which is crucial in the synthesis of various peptides and proteins.
Used in Pharmaceutical Industry:
9-FLUORENYLIDENEACETIC ACID is used as a potential anti-inflammatory and anti-cancer agent in medicinal chemistry research. Its potential properties make it a subject of interest for the development of new drugs and therapies.
Used in Agriculture:
9-FLUORENYLIDENEACETIC ACID is used as a plant growth regulator in agriculture. Research indicates that it may have the ability to promote the growth and development of various plants, making it a potential tool for enhancing crop yields and improving plant health.

InChI:InChI=1/C15H10O2/c16-15(17)9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-9H,(H,16,17)/p-1

Upstream product

• 486-25-9 9-fluorenone 
• 4425-71-2 2-(9H-fluoren-9-ylidene)acetaldehyde 
• 105-36-2 ethyl bromoacetate 
• 13461-74-0 9-ethynylfluoren-9-ol 
• 18083-73-3 <9-Brom-fluorenyl-(9)>-bromessigsaeure-aethylester 
• 872280-79-0 ethyl 2-(9H-fluoren-9-yl)-2-hydroxyacetate 
• 18083-76-6 Fluorenyliden-bromessigsaeure 
• 18083-74-4 Fluorenyliden-bromessigsaeure-ethylester 
• 27973-36-0 dibenzofulvenecarboxylic acid ethyl ester 
• 141-52-6 sodium ethanolate 

Downstream Products

• 65779-23-9 3-{4-[2-(2-Fluoren-9-ylidene-acetylamino)-ethyl]-phenyl}-propionic acid ethyl ester 
• 486-25-9 9-fluorenone 
• 96784-34-8 4'-Carbamoylspiro-5'-one 
• 1195760-09-8 N-(2-aminophenyl)-6-(2-(2-(9H-fluoren-9-ylidene)acetamido)-ethylamino)nicotinamide 
• 1195760-11-2 N-(2-aminophenyl)-6-(3-(2-(9H-fluoren-9-ylidene)acetamido)-propylamino)nicotinamide 
• 1195760-13-4 N-(2-aminophenyl)-6-(4-(2-(9H-fluoren-9-ylidene)acetamido)-butylamino)nicotinamide 
• 1195760-15-6 N-(2-amino-4-fluorophenyl)-6-(2-(2-(9H-fluoren-9-ylidene)-acetamido)ethylamino)-nicotinamide 
• 1195760-17-8 N-(2-amino-4-fluorophenyl)-6-(3-(2-(9H-fluoren-9-ylidene)-acetamido)propylamino)-nicotinamide 
• 1195760-19-0 N-(2-amino-4-fluorophenyl)-6-(4-(2-(9H-fluoren-9-ylidene)-acetamido)butylamino)-nicotinamide 
• 1195760-21-4 N-(2-amino-4-chlorophenyl)-6-(2-(2-(9H-fluoren-9-ylidene)-acetamido)ethylamino)-nicotinamide 
• 1195760-23-6 N-(2-amino-4-methylphenyl)-6-(2-(2-(9H-fluoren-9-ylidene)-acetamido)ethylamino)-nicotinamide 
• 1195760-25-8 N-(2-amino-4-methoxyphenyl)-6-(2-(2-(9H-fluoren-9-ylidene)-acetamido)ethylamino)-nicotinamide 
• 1195760-27-0 N-(2-amino-4-trifluoromethyl-phenyl)-6-(2-(2-(9H-fluoren-9-ylidene)acetamido)ethylamino)-nicotinamide 
• 1195760-41-8 N-(2-aminophenyl)-6-(6-(2-(9H-fluoren-9-ylidene)acetamido)-hexylamino)nicotinamide 

Relevant academic research and scientific papers

UREA DERIVATIVES USEFUL AS CALCIUM RECEPTOR MODULATORS

The present invention provides compounds of formula (I): in which Y is oxygen or sulphur; R1 and R”1 are optionally substituted aryl, heteroaryl or a fused ring structure, R2and R'2 are each H, or optionally substituted alkyl, alkylaminoalkyl or dialkylaminoalkyl, or R2 and R'2 and their N form a saturated or unsaturated optionally substituted heterocycle, R3 represents a group of formula -(CH2)P-Ar-Rn, wherein p is 0 or 1 and, when p is 1, is optionally substituted, Ar is aryl or heteroaryl, and each R is H, halogen; hydroxyl; trifiuoromethyl; linear and branched alkyl, alkenyl, alkynyl, and alkoxyl groups, all optionally further substituted by one or more of hydroxy groups, halogen atoms, alkoxy groups, amino groups, and alkylthio groups; linear and branched alkoxyl groups; linear and branched thioalkyl groups; aryl groups; aralkyl groups; aralkoxy groups; aryloxy groups; perfluoroalkyl; -CN; -NR4R5, -C(=X)NR4R5,-O-C(=X)NR4R5, -SO2NR4R5, - Alk-NR4R5, -NZC(=X)(NH)qR6, -Alk-NZC(=X)(NH)qR6, -C(=X)R6, -Alk-C(=X)(NH)qR6, -NHSO2R7, -SO2R7, -SOR7, -SR7, or is a saturated or unsaturated heterocyclyl group, and salts and esters thereof, are useful in the treatment of conditions susceptible to modulating ion channels, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF

The present invention provides compounds of formula (I): in which R 1, R'1, R2, R'2, R3, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

Reaction of Olefins with Malonamide in the Presence of Manganese(III) Acetate. Formation of α,β-Unsaturated γ-Lactones and γ-Lactams

The reaction of olefins with malonamide in the presence of manganese(III) acetate gave 2-buten-4-olides and/or 1H-pyrrol-2(5H)-ones in one-step, short reaction time and moderate yields.The product distribution can be accounted for in terms of the stabilization of the intermediate carbocation in the oxidation process.The synthetic application and limitation, and the oxidation mechanism for the formations of α,β-unsaturated γ-lactones and γ-lactams are discussed.