trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indole]-2,2'''(1H,1'''H)-dione, also known as JW 67, is a novel synthetic antagonist of canonical Wnt signaling. It is a complex organic compound with a unique trispiro structure, consisting of three fused indole and dioxane rings. JW 67 has been found to inhibit the growth of human colorectal cancer cells and downregulate Wnt target genes, making it a promising candidate for cancer treatment.
442644-28-2
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Basic information
- Product Name: Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)
- Synonyms: JW67;Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI);trispiro[indoline-3,2-1,3-dioxane-5,5-1,3-dioxane-2,3-indoline]-2,23-dione
- CAS NO:442644-28-2
- Molecular Formula: C21H18N2O6
- Molecular Weight: 394.37742
- EINECS: N/A
- Product Categories: N/A
- Mol File: 442644-28-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white to beige/
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: DMSO: >5mg/mL
- CAS DataBase Reference: Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)(CAS DataBase Reference)
- NIST Chemistry Reference: Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)(442644-28-2)
- EPA Substance Registry System: Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)(442644-28-2)
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Safety Data
- Hazard Codes: T
- Statements: 25
- Safety Statements: 45
- RIDADR: UN 2811 6.1 / PGIII
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 442644-28-2(Hazardous Substances Data)
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442644-28-2 Usage
Uses
Used in Oncology:JW 67 is used as an antagonist of canonical Wnt signaling for the treatment of colorectal cancer. It inhibits the growth of cancer cells and downregulates Wnt target genes, which play a crucial role in the development and progression of colorectal cancer. By targeting the Wnt signaling pathway, JW 67 has the potential to provide a novel therapeutic approach for patients with colorectal cancer.
Used in Drug Development:
JW 67 is used as a lead compound in the development of new drugs targeting the Wnt signaling pathway. Its unique structure and mechanism of action make it an attractive candidate for further research and optimization. By understanding the interactions between JW 67 and its target, researchers can design more potent and selective Wnt antagonists with improved pharmacological properties.
Used in Cancer Research:
JW 67 is used as a research tool to study the role of canonical Wnt signaling in colorectal cancer and other malignancies. Its ability to inhibit Wnt target genes and cancer cell growth provides valuable insights into the molecular mechanisms underlying tumor development and progression. Additionally, JW 67 can be used to evaluate the efficacy of combination therapies with other anticancer agents, potentially leading to the discovery of novel treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 442644-28-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,2,6,4 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.Calculate Digit Verification of CAS Registry Number 442644-28:
(8*4)+(7*4)+(6*2)+(5*6)+(4*4)+(3*4)+(2*2)+(1*8)=142
142 % 10 = 2
So 442644-28-2 is a valid CAS Registry Number.
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Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)
