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Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 31230-17-8 3-methyl-5-aminopyrazole 
• 100-52-7 benzaldehyde 
• 31230-17-8 3-amino-5-methylpyrazole 

Relevant academic research and scientific papers

Design, synthesis, characterization, and catalytic properties of g-C3N4-SO3H as an efficient nanosheet ionic liquid for one-pot synthesis of pyrazolo[3,4-b]pyridines and bis(indolyl)methanes

A novel sulfonic-functionalized ionic liquid, C3N4 (C3N4-SO3H (IL)), was prepared and its structure was characterized using FTIR, TEM, XRD, CHNS elemental analysis and FESEM-EDX mapping. Catalytic act

Novel nano-titania embedded on graphite (nano-TiO2@Cg) as an efficient, eco-friendly, and recyclable catalyst for one-pot, solvent-free synthesis of 4-aryl-3,4-dihydroquinolin-2(1H)-ones, 3-methyl-4-aryl/alkyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones, and coumarin-3-carboxylic esters

Abstract: A novel acid catalyst has been synthesized by commercial anatase phase nano-TiO2 and graphite (nano-TiO2@Cg) via a simple procedure and characterized by Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, field emission scanning electron microscopy, and potentiometric titration techniques. It has been utilized as a convenient nano-catalyst to accelerate the one-pot, solvent-free, three-component reaction of Meldrum’s acid, aromatic amines (5-methylpyrazol-3-amine), and various aromatic aldehydes to form 4-aryl-3,4-dihydroquinolin-2-(1H)-ones and 3-methyl-4-aryl/alkyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones, respectively. The catalytic activity has also examined for the preparation of coumarin-3-carboxylic esters from Meldrum’s acid, salicylaldehydes, and alcohols successfully. Low catalyst loading, clean process without utilizing any hazardous solvent, easy workup procedure, reusability and recyclability of the nano-catalyst within four runs without activity loss, high yields of the products, in addition with utilizing a vast range of substrates are some highlighted points of the reported protocols. Graphical abstract: [Figure not available: see fulltext.]

Mesoporous SBA-15 Silica Phenylsulfonic Acid (SBA-15-Ph-SO3H) as Efficient Nanocatalyst for One-pot Three-component Synthesis of 3-Methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones

A simple, economical, and efficient approach to the one-pot synthesis of 3-methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by multicomponent assembling of 5-methylpyrazol-3-amine, aldehydes, and Meldrum's acid using mesoporous silica phenylsulfonic acid (SBA-15-Ph-SO3H) as recyclable and heterogonous solid acid nanocatalyst has been described. This protocol has the advantages of high yields, wide application scope, and an environmental benign procedure.

One-pot Green Synthesis of 3-Methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by Multicomponent Assembling of 5-Methylpyrazol-3-amine, Aldehydes, and Meldrum's Acid Using Sodium Dodecyl Sulfate (SDS) in Water

A simple, economical, and green approach to the one-pot synthesis of 3-methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by multicomponent assembling of 5-methylpyrazol-3-amine, aldehydes, and Meldrum's acid using sodium dodecyl sulfate as surfactant in water is described. This protocol has the advantages of high yields, wide application scope, and an environmental benign procedure.

A new nano-Fe3O4-supported organocatalyst based on 3,4-dihydroxypyridine: an efficient heterogeneous nanocatalyst for one-pot synthesis of pyrazolo[3,4-b]pyridines and pyrano[2,3-d]pyrimidines

A simple and practical strategy for the synthesis of a novel nano-Fe3O4-supported organocatalyst system based on 3,4-dihydroxypyridine (Fe3O4/Py) has been developed. The prepared catalyst was characterized using

A green, efficient and recyclable Fe+3@K10 catalyst for the synthesis of bioactive pyrazolo[3,4-b]pyridin-6(7H)-ones under on water conditions

An efficient regioselective one-pot three-component synthesis of 4-aryl-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-ones and their bis-derivatives (Table 3 and Fig. 2) catalyzed by Fe+3-K10 montmorillonite (Fe+3@K10) under the Sharpless conditions ( On water contdiions) is described. This rapid method produced the products in short reaction times (10-15 min) and excellent yields (87-95%). The antibacterial activity of the synthesized products was examined. Some products showed promising activities.

An efficient regioselective sonochemical synthesis of novel 4-aryl-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-ones

An efficient ultrasound-assisted preparation of a series of novel 4-aryl-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-ones via the reaction of 5-amino-3-methyl-1H-pyrazole, Meldrum's acid and various arylaldehydes using one-pot three-component approach is described. This rapid method produced the products in short reaction times (3-4 min) and excellent yields (87-95%).

New multicomponent domino reactions (MDRs) in water: Highly chemo-, regio- and stereoselective synthesis of spiro{[1,3]dioxanopyridine}-4,6-diones and pyrazolo[3,4-b]pyridines

New multicomponent domino reactions (MDRs) have been established for the synthesis of spiro{pyrazolo[1,3]dioxanopyridine}-4,6-diones, spiro{isoxazolo[1,3]dioxanopyridine}-4,6-diones and pyrazolo[3,4-b]pyridines. The MDRs were conducted by reacting readily available and inexpensive starting materials in aqueous solution under microwave irradiation. A total of 26 examples were examined, and showed a broad substrate scope and high overall yields (76-93%). A new mechanism has been proposed to explain the reaction process and the resulting chemo-, regio- and stereoselectivity. The present green synthesis shows attractive characteristics such as the use of water as the reaction medium, one-pot conditions, short reaction periods (9-13 min), easy work-up/purification and reduced waste production without the use of any acids or metal promoters.