442652-79-1

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 31230-17-8 3-amino-5-methylpyrazole 
• 31230-17-8 3-methyl-5-aminopyrazole 

Relevant academic research and scientific papers

A new nano-Fe3O4-supported organocatalyst based on 3,4-dihydroxypyridine: an efficient heterogeneous nanocatalyst for one-pot synthesis of pyrazolo[3,4-b]pyridines and pyrano[2,3-d]pyrimidines

A simple and practical strategy for the synthesis of a novel nano-Fe3O4-supported organocatalyst system based on 3,4-dihydroxypyridine (Fe3O4/Py) has been developed. The prepared catalyst was characterized using

Design, synthesis, characterization, and catalytic properties of g-C3N4-SO3H as an efficient nanosheet ionic liquid for one-pot synthesis of pyrazolo[3,4-b]pyridines and bis(indolyl)methanes

A novel sulfonic-functionalized ionic liquid, C3N4 (C3N4-SO3H (IL)), was prepared and its structure was characterized using FTIR, TEM, XRD, CHNS elemental analysis and FESEM-EDX mapping. Catalytic act

Novel nano-titania embedded on graphite (nano-TiO2@Cg) as an efficient, eco-friendly, and recyclable catalyst for one-pot, solvent-free synthesis of 4-aryl-3,4-dihydroquinolin-2(1H)-ones, 3-methyl-4-aryl/alkyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones, and coumarin-3-carboxylic esters

Abstract: A novel acid catalyst has been synthesized by commercial anatase phase nano-TiO2 and graphite (nano-TiO2@Cg) via a simple procedure and characterized by Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, field emission scanning electron microscopy, and potentiometric titration techniques. It has been utilized as a convenient nano-catalyst to accelerate the one-pot, solvent-free, three-component reaction of Meldrum’s acid, aromatic amines (5-methylpyrazol-3-amine), and various aromatic aldehydes to form 4-aryl-3,4-dihydroquinolin-2-(1H)-ones and 3-methyl-4-aryl/alkyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones, respectively. The catalytic activity has also examined for the preparation of coumarin-3-carboxylic esters from Meldrum’s acid, salicylaldehydes, and alcohols successfully. Low catalyst loading, clean process without utilizing any hazardous solvent, easy workup procedure, reusability and recyclability of the nano-catalyst within four runs without activity loss, high yields of the products, in addition with utilizing a vast range of substrates are some highlighted points of the reported protocols. Graphical abstract: [Figure not available: see fulltext.]

One-pot Green Synthesis of 3-Methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by Multicomponent Assembling of 5-Methylpyrazol-3-amine, Aldehydes, and Meldrum's Acid Using Sodium Dodecyl Sulfate (SDS) in Water

A simple, economical, and green approach to the one-pot synthesis of 3-methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by multicomponent assembling of 5-methylpyrazol-3-amine, aldehydes, and Meldrum's acid using sodium dodecyl sulfate as surfactant in water is described. This protocol has the advantages of high yields, wide application scope, and an environmental benign procedure.

Mesoporous SBA-15 Silica Phenylsulfonic Acid (SBA-15-Ph-SO3H) as Efficient Nanocatalyst for One-pot Three-component Synthesis of 3-Methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones

A simple, economical, and efficient approach to the one-pot synthesis of 3-methyl-4-aryl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridine-6-ones by multicomponent assembling of 5-methylpyrazol-3-amine, aldehydes, and Meldrum's acid using mesoporous silica phenylsulfonic acid (SBA-15-Ph-SO3H) as recyclable and heterogonous solid acid nanocatalyst has been described. This protocol has the advantages of high yields, wide application scope, and an environmental benign procedure.

A green, efficient and recyclable Fe+3@K10 catalyst for the synthesis of bioactive pyrazolo[3,4-b]pyridin-6(7H)-ones under on water conditions

An efficient regioselective one-pot three-component synthesis of 4-aryl-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-ones and their bis-derivatives (Table 3 and Fig. 2) catalyzed by Fe+3-K10 montmorillonite (Fe+3@K10) under the Sharpless conditions ( On water contdiions) is described. This rapid method produced the products in short reaction times (10-15 min) and excellent yields (87-95%). The antibacterial activity of the synthesized products was examined. Some products showed promising activities.

An efficient regioselective sonochemical synthesis of novel 4-aryl-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-ones

An efficient ultrasound-assisted preparation of a series of novel 4-aryl-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-ones via the reaction of 5-amino-3-methyl-1H-pyrazole, Meldrum's acid and various arylaldehydes using one-pot three-component approach is described. This rapid method produced the products in short reaction times (3-4 min) and excellent yields (87-95%).

New multicomponent domino reactions (MDRs) in water: Highly chemo-, regio- and stereoselective synthesis of spiro{[1,3]dioxanopyridine}-4,6-diones and pyrazolo[3,4-b]pyridines

New multicomponent domino reactions (MDRs) have been established for the synthesis of spiro{pyrazolo[1,3]dioxanopyridine}-4,6-diones, spiro{isoxazolo[1,3]dioxanopyridine}-4,6-diones and pyrazolo[3,4-b]pyridines. The MDRs were conducted by reacting readily available and inexpensive starting materials in aqueous solution under microwave irradiation. A total of 26 examples were examined, and showed a broad substrate scope and high overall yields (76-93%). A new mechanism has been proposed to explain the reaction process and the resulting chemo-, regio- and stereoselectivity. The present green synthesis shows attractive characteristics such as the use of water as the reaction medium, one-pot conditions, short reaction periods (9-13 min), easy work-up/purification and reduced waste production without the use of any acids or metal promoters.