442850-72-8

Upstream product

• 7400-27-3 tertbutylhydrazine hydrochloride 
• 614-16-4 Benzoylacetonitrile 

Downstream Products

• 817641-87-5 1-tert-butyl-3-cyclobutyl-4-methyl-1,7-dihydro-pyrazolo[3,4-b]pyridin-6-one 
• 1023655-00-6 C₃₂H₃₉N₇O₃S 
• 77493-73-3 4,7-dihydro-2-phenylpyrazolo[1,5-a]pyrimidin-7-one 
• 1603826-70-5 4-phenyl-6H-pyrazolo[3,4-c]isothiazole-3-carboxamide 
• 1603826-68-1 6-(tert-butyl)-4-phenyl-6H-pyrazolo[3,4-c]isothiazole-3-carboxamide 
• 1603826-48-7 4-phenyl-6H-pyrazolo[3,4-c]isothiazole-3-carbonitrile 
• 1603826-53-4 6-(tert-butyl)-4-phenyl-6H-pyrazolo[3,4-c]isothiazole-3-carbonitrile 
• 442850-80-8 N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-thiobenzamide 
• 442850-83-1 N-(5-phenyl-2H-pyrazol-3-yl)-thiobenzamide 
• 442850-74-0 N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-benzamide 

Relevant academic research and scientific papers

HSP90 INHIBITORS AND USES THEREOF

Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related deseases.

Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence, and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen's hu

Gas-phase synthesis of pyrazolo[3,4- b ]pyridin-4-ones

Flash vacuum pyrolysis (FVP) at 500-600 °C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum's acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750-850 °C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.

2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS

The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

PYRAZOLO`3,4-B!PYRIDIN-6-ONES AS GSK-3 INHIBITORS

The invention provides compounds of formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R2, and R3 are as defined herein; pharmaceutical compositions thereof; and use thereof in the treatment of, inter alia, conditions, diseases, and symptoms such as diabetes, dementia, Alzheimer's Disease, stroke, schizophrenia, depression, hair loss, and cancer.