442850-74-0

Basic information

• Product Name: N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-benzamide
• Synonyms: N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-benzamide
• CAS NO: 442850-74-0
• Molecular Weight: 319.406
• Mol File: 442850-74-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-benzamide(442850-74-0)
• EPA Substance Registry System: N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-benzamide(442850-74-0)

Safety Data

• Hazardous Substances Data: 442850-74-0(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 442850-72-8 1-(tert-butyl)-3-phenyl-1H-pyrazol-5-amine 

Downstream Products

• 442850-83-1 N-(5-phenyl-2H-pyrazol-3-yl)-thiobenzamide 
• 442850-80-8 N-(2-tert-butyl-5-phenyl-2H-pyrazol-3-yl)-thiobenzamide 

Relevant articles and documents

Development of new fungicides against Magnaporthe grisea: Synthesis and biological activity of pyrazolo[3,4-d][1,3]thiazine, pyrazolo[1,5-c][1,3,5]thiadiazine, and pyrazolo[3,4-d]pyrimidine derivatives

Some pyrazolo[3,4-d]pyrimidin-4(5H)-thione, pyrazolo[3,4-d][1,3]thiazin-4-one/thione, and pyrazolo[1,5-c][1,3,5]thiadiazine-4-one/thione derivatives were synthesized and screened for antifungal activity against the causal agent of rice blast disease, Magnaporthe grisea. In all cases a remarkable inhibition of fungal growth was found in the range from 10 to 200 μg mL-1. Several compounds were able to control mycelium growth at a rate of 10 μg mL-1, a concentration at which the reference compound tricyclazole was completely ineffective. At least in the case of the most active substance, at the same dose the growth of seedlings or cultured cells of rice was substantially unaffected. Results allowed definition of structural requirements either to maintain or to enhance mycotoxic activity.