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442907-10-0

7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine is a complex organic compound with the molecular formula C10H9N5O. It features a triazolo[4,5-d]pyrimidine core, which is a heterocyclic ring system containing three nitrogen atoms and one oxygen atom. The compound is characterized by a 5-amino group attached to the triazolo[4,5-d]pyrimidine ring and a 5-methyl-2-furyl substituent at the 7-position. This molecule is of interest in the field of medicinal chemistry and may have potential applications in the development of new drugs due to its unique structure and properties.

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  • 442907-10-0 Structure

  • Basic information

    1. Product Name: 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine
    2. Synonyms: 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine
    3. CAS NO:442907-10-0
    4. Molecular Formula:
    5. Molecular Weight: 216.202
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 442907-10-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine(442907-10-0)
    11. EPA Substance Registry System: 7-(5-methyl-2-furyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5-amine(442907-10-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 442907-10-0(Hazardous Substances Data)

442907-10-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 442907-10-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,2,9,0 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 442907-10:
(8*4)+(7*4)+(6*2)+(5*9)+(4*0)+(3*7)+(2*1)+(1*0)=140
140 % 10 = 0
So 442907-10-0 is a valid CAS Registry Number.

442907-10-0Relevant articles and documents

Antagonists of the human A2A adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines

Gillespie, Roger J.,Bamford, Samantha J.,Botting, Ruth,Comer, Mike,Denny, Sarah,Gaur, Suneel,Griffin, Michael,Jordan, Allan M.,Knight, Anthony R.,Lerpiniere, Joanne,Leonardi, Stefania,Lightowler, Sean,McAteer, Steven,Merrett, Angela,Misra, Anil,Padfield, Antony,Reece, Mark,Saadi, Mona,Selwood, Daniel L.,Stratton, Gemma C.,Surry, Dominic,Todd, Richard,Tong, Xin,Ruston, Vicki,Upton, Rebecca,Weiss, Scott M.

, p. 33 - 47 (2011/04/19)

Antagonism of the human A2A receptor has been implicated as a point of therapeutic intervention in the alleviation of the symptoms associated with Parkinson's disease. This is thought to occur, at least in part, by increasing the sensitivity of the dopaminergic neurons to the residual, depleted levels of striatal dopamine. We herein describe a novel series of functionalized triazolo[4,5-d]pyrimidine derivatives that display functional antagonism of the A2A receptor. Optimization of these compounds has resulted in improvements in potency, selectivity, and the pharmacokinetic properties of key derivatives. These efforts have led to the discovery of 60 (V2006/BIIB014), which demonstrates strong oral activity in commonly used models of Parkinson's disease. Furthermore, this derivative has shown excellent preclinical pharmacokinetics and has successfully completed phase I clinical studies. This compound is presently undergoing further clinical evaluation in collaboration with Biogen Idec.

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