442907-49-5Relevant academic research and scientific papers
Alkoxypyrazoles and the process for their preparation
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Page/Page column 9; 15, (2010/03/02)
The present invention relates to a alkoxypyrazoles preparation process, and new alkoxypyrazole compounds.
An improved preparation of 3-alkoxypyrazoles
Guillou, Sandrine,Bonhomme, Frederic J.,Janin, Yves L.
experimental part, p. 3504 - 3508 (2009/05/09)
The condensation between alkyl acetoacetates and hydrazines constitutes the very well-known Knorr synthetic method leading to pyrazol-3/5-ones. However, contemporary reports describe an alternate reaction pathway leading to low yields of 3/5-alkoxypyrazoles using hydrazine salts. No general method for the selective synthesis of 3-alkoxypyrazoles has been reported to date, hence we focused on this side reaction in an attempt to turn it into the main transformation. Depending on the starting material, various 3-alkoxypyrazoles (methoxy, ethoxy, benzyloxy, isopropoxy, allyloxy) were obtained in up to 56% yield. Georg Thieme Verlag Stuttgart.
