4430-49-3

Usage

Uses

Used in Pharmaceutical Industry:
ISOTHIOCYANATOPHENYL SULFONE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
ISOTHIOCYANATOPHENYL SULFONE is used as a pesticide and herbicide, leveraging its capacity to inhibit the growth of harmful microorganisms and weeds, thereby enhancing crop protection and yield.
Used in Cancer Research:
ISOTHIOCYANATOPHENYL SULFONE is being investigated for its potential use in the development of anti-cancer drugs, due to its ability to target and inhibit the growth of cancer cells, offering a new avenue for cancer treatment.
Used in Inflammation Management:
ISOTHIOCYANATOPHENYL SULFONE is also being explored for its potential in the creation of anti-inflammatory drugs, given its capacity to modulate inflammatory responses, which could be beneficial in treating various inflammatory conditions.
It is important to handle and store ISOTHIOCYANATOPHENYL SULFONE with caution due to its potential irritant and toxic properties, ensuring safety in its application and use.

InChI:InChI=1/C14H8N2O2S3/c17-21(18,13-7-3-1-5-11(13)15-9-19)14-8-4-2-6-12(14)16-10-20/h1-8H

Upstream product

• 139-65-1 4,4'-thiobisaniline 
• 80-08-0 dapsone 
• 463-71-8 thiophosgene 

Downstream Products

• 1159841-42-5 4,4'-bis[thiocarbamic acid O-methyl ester]-1,1'-diphenyl sulfone 
• 1159841-43-6 4,4'-bis[thiocarbamic acid O-propyl ester]-1,1'-diphenyl sulfone 
• 1159841-44-7 4,4'-bis[3-propyl-2-thioxo]-1,1'-diphenyl sulfone 
• 99250-04-1 4,4'-bis[thiocarbamic acid O-ethyl ester]-1,1'-diphenyl sulfone 
• 110063-17-7 1,1′-(4,4′-sulfonylbis(4,1-phenylene))dithiourea 
• 1159841-48-1 4,4'-bis(benzoylthiosemicarbazid-4-yl)-1,1'-diphenyl sulfone 
• 1159841-45-8 4,4'-bis(5-amino-3-thioxo-2,4-dihydro-1,2,4-triazol-4-yl)-1,1'-diphenyl sulfone 
• 1159841-46-9 C₁₆H₁₆N₁₀O₂S₃ 
• 473401-40-0 4,4'-bis[3-butyl-2-thioxo]-1,1'-diphenyl sulfone 
• 1159841-47-0 4,4'-bis(phenylthiosemicarbazid-4-yl)-1,1'-diphenyl sulfone 
• 101319-22-6 4,4'-bis(3-carboxymethyl-thioureido)-1,1'-diphenyl sulfone 
• 100262-59-7 4,4'-bis[thiocarbamic acid O-butyl ester]-1,1'-diphenyl sulfone 
• 1159588-79-0 4,4'-bis(5-imino-1-(4-methoxyphenyl)-2,4-dithioxo-imidazolidin-3-yl)-1,1'-diphenylsulfone 
• 1159588-78-9 4,4'-bis(5-imino-1-(4-tolyl)-2,4-dithioxo-imidazolidin-3-yl)-1,1'-diphenylsulfone 

Relevant academic research and scientific papers

NSCLC structure-activity relationship (sar) study of diisothiocyanates for antiproliferative activity on A549 Human non-small cell lung carcinoma (NSCLC)

Isothiocyanate functional group (-N=C=S) is widely accepted as an important moiety for anti-cancer effects of naturally occurring isothiocyanate compounds (ITCs). Herein, a series of diisothiocyanate (diITCs) derivatives were synthesized and evaluated in antiproliferative assays on A549 human non-small cell lung cancer and IMR90 human foetal lung cell lines for structure-activity relationship (SAR) and cancer cell selectivity studies. Results showed that aliphatic and benzylic diITCs were more cytotoxic to A549 cells than natural ITCs; benzyl isothiocyanate (BITC) and phenyl isothiocyanate (PITC), and a currently available anticancer drug; etoposide. Aromatic diITCs were not as active. Notably, most of the diITCs reported in this work were significantly more selective than etoposide to inhibit proliferation of the cancer cells (A549) over the normal cells (IMR90). This study demonstrated a guideline to modify chemical structures of diITCs for anti-NSCLC agents.

Dapson in heterocyclic chemistry, part I: Novel synthesis of sulfone biscompounds for antimicrobial and antitumor activities

This article describes the synthesis of some novel sulfone bis-compounds bearing the biologically active thioether 3-6; thioureido 7, 8, 15, 16; triazole 10, 11; thiosemicarbazido 9, 12, 13; and 1,3,4-thiadiazole 14, 17 moieties starting with 4,4′-diisoth

Dapson in heterocyclic chemistry, part II: Antimicrobial and antitumor activities of some novel sulfone biscompounds containing biologically active thioureido, carbamothioate, quinazoline, imidazolidine, and thiazole moieties

The reaction of 4,4′-diisothiocyanato-1,1-diphenylsulfone 2 with aromatic amines and phenol derivatives afforded the corresponding thioureio derivatives 3-9, respectively. Also, the reaction of 2 with catechol gave the corresponding carbamothioate derivat

Dapson in heterocyclic chemistry, part III: Synthesis, antimicrobial, and antitumor activities of some new bisheterocyclic compounds containing biologically active diphenylsulfone moiety

The key intermediate diisothiocyanate 2 was allowed to react with 5-amino-3-methyl-pyrazole-4-carbonitrile 3, ethyl 5-amino-1-phenyl-pyrazole-4- carboxylate 6, 2-amino-tetrahydrobenzo[b]thiophene-3-car-bonitrile 9, ethyl-2-amino-tetra-hydrobenzo[b]thiophe

Rapid synthesis of 2-cyanobenzothiazole, isothiocyanate and cyanoformanilide derivatives of dapsone

The rapid synthesis of 2-cyanobenzothiazole, isothiocyanate and cyanoformanilide derivatives of dapsone was examined. The derivatives of the leprostatic drug dapsone were prepared by way of imino-1,2,3-dithiazoles obtained by condensation of aromatic prim