4430-77-7

Usage

Uses

6,7-Dihydro-pyrido[2,3-d]pyridazine-5,8-dione

InChI:InChI=1/C7H5N3O2/c11-6-4-2-1-3-8-5(4)7(12)10-9-6/h1-3H,(H,9,11)(H,10,12)

Upstream product

• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 605-38-9 dimethyl 2,3-pyridinedicarboxylate 
• 76240-65-8 C₂₁H₁₃N₃O₂ 
• 91533-15-2 pyrido<2,3-d>pyridazine-5,8-dione 
• 23439-87-4 6-hydroxy-5H-pyrrolo[3,4-b]pyridine-5,7-(6H)-dione 
• 55155-23-2 2,3-pyridinedicarboxylic acid chloride 

Downstream Products

• 2398-81-4 Nicotinic acid N-oxide 
• 89663-08-1 pyrido<2,3-d>pyridazine-5,8-dione 1-oxide 
• 703-33-3 5,8-Dichloropyrido<2,3-d>pyridazine 
• 2942-32-7 6-Chloro-1,2,4-triazolo<4,3-b>pyrido<2,3-d>pyridazine 
• 2843-74-5 (5-chloro-pyrido[2,3-d]pyridazin-8-yl)-phenyl-amine 
• 2843-76-7 (4-chloro-phenyl)-(5-chloro-pyrido[2,3-d]pyridazin-8-yl)-amine 
• 2843-78-9 (4-bromo-phenyl)-(5-chloro-pyrido[2,3-d]pyridazin-8-yl)-amine 

Relevant academic research and scientific papers

2-D lanthanide-organic complexes constructed from 6,7-dihydropyrido(2,3-d) pyridazine-5,8-dione: Synthesis, characterization and photoluminescence for sensing small molecules

Four isostructural lanthanide-organic complexes [Ln(HPDH)(ox)(H 2O)]n (Ln = Eu3+1, Tb3+2, Sm 3+3, Gd3+4; H2PDH = 6,7-dihydropyrido(2,3-d) pyridazine-5,8-dione; H2ox = oxalic acid) have been synthesized successfully under hydrothermal conditions and characterized by means of elemental analysis, powder XRD, TG-DTA, IR and UV-vis spectroscopy. Complexes 1 and 2 were structurally characterized by single crystal X-ray diffraction analysis. All complexes are composed of 2-D layers, which further construct a 3-D supramolecular network. Each 2-D layer in complexes 1-4 is composed of 1-D Eu-ox infinite chains, which are further connected by biconnected HPDH - ligands. The photoluminescent properties of complexes 1-4 were studied in the solid state at room temperature. The singlet energy level (34722 cm-1) and the lowest triplet energy level (21786 cm-1) for the ligand H2PDH were calculated on the basis of its UV-vis absorbance edges (1 × 10-4 M in ethanol) and phosphorescence spectrum of complex 4 at 77 K, respectively. The complexes 1, 2, and 3 exhibit metal centered luminescence with characteristic red, green and pink emission, respectively. The energy transfer mechanism and photoluminescence properties were investigated. Complex 1, in which the energy transition from the triplet energy level (3ππ*) of ligand HPDH- to Eu3+ cation is more effective, has been selected as a representative to examine the potential for sensing small molecules by its luminescence properties in different emulsions. EtOH was found to be an excellent enhancing while DMF a highly quenching solvent in this study.

A series of mononuclear lanthanide complexes featuring 3-D supramolecular networks: Synthesis, characterization and luminescent properties for sensing guest molecules

A new series of four isostructural mononuclear lanthanide complexes Ln(HPDH)3(H2O)3·H2O (Ln = Sm(iii) 1, Eu(iii) 2, Tb(iii) 3 and Dy(iii) 4; H2PDH = 6,7-dihydropyrido(2,3-d)pyridazine-5,8-dione) has been prepared and characterized by IR, elemental analysis, XRD and TG-DTA methods. Single crystal X-ray diffraction analysis of both complexes 1 and 3 revealed that the mononuclear discrete complexes form 3-D supramolecular networks via hydrogen bonds and offset stacking (-H...π) interactions. The photoluminescence study of the title complexes revealed the photoluminescent potential of the antenna ligand (H2PDH) toward the concerned lanthanide cations. The luminescence based sensing ability of the partially dehydrated complex Tb(HPDH)3(H2O)33a towards small solvent molecules, along with its reusability, has been studied. Isopropyl alcohol was found to be an excellent sensitizer, while tetrahydrofuran was a highly quenching solvent with a first order behavior towards the photoluminescence intensity. The photoluminescence intensity was found to decrease with the increase of the dielectric constant and normalized Dimroth-Reichardt E T parameter values for protic solvents, while reverse behavior was observed for dipolar aprotic solvents.

KRAS G12C INHIBITORS AND METHODS OF USING THE SAME

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

KRAS G12C INHIBITORS AND METHODS OF USING THE SAME

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

KRAS G12C INHIBITORS AND METHODS OF USING THE SAME

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

1, 2, 3, 4- [...] compound and process for the synthesis of

The invention provides a synthetic and technological method of a 1,2,3,4-tetrahydrophthalazine compound used as an intermediate of bactericides and anti HIV (human immunodeficiency virus) and other new drugs. The 1,2,3,4-tetrahydrophthalazine compound is obtained by using various cheap and easily accessible phthalic acid or phthalic anhydride as a raw material for two steps of reaction. The method is easily accessible in raw material, low in cost, simple in reaction, easy in control, simple in processing and easy in amplification, and a large number of industrial by-product hydrazide can be found to be directly used as a raw material for the second step. The method is convenient to economic, reuses the industrial by-product as the raw material, and provides a feasible synthetic production and technological method of the 1,2,3,4-tetrahydrophthalazine compound for green chemical industry.

Design, synthesis of 6-substituted-pyrido[3,2-d]pyridazine derivatives with anticonvulsant activity

Aim to find new compounds with stronger anticonvulsant activity and lower neurotoxicity, a novel series of 6-substituted-pyrido[3,2-d]pyridazine derivatives was synthesized using furo[3,4-b]pyridine-5,7-dione as the starting material. We evaluated their a

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines

Pyridopyridazine antagonists of the hedgehog signaling pathway are described. Designed to optimize our previously described phthalazine smoothened antagonists, a representative compound eliminates a PXR liability while retaining potency and in vitro metab

ANNELATED PYRIDAZINES FOR THE TREATMENT OF TUMORS DRIVEN BY INAPPROPRIATE HEDGEHOG SIGNALLING

The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.

Pentaaza-cyclopental[a]naphthalene derivatives as ligands for GABAa α5 receptors

A class of 1,2,3a,4,x-pentaaza-cyclopenta[a]naphthalene compounds (x=6, 7, 8 or 9) is described. The compounds have a high affinity for the GABAAα5 receptors and show inverse agonist activity thereat. The compounds are useful in therapy where cognition enhancement is required.