443103-51-3Relevant academic research and scientific papers
Development of18f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation
Lai, Thu Hang,Schr?der, Susann,Toussaint, Magali,Duki?-Stefanovi?, Sladjana,Kranz, Mathias,Ludwig, Friedrich-Alexander,Fischer, Steffen,Steinbach, J?rg,Deuther-Conrad, Winnie,Brust, Peter,Moldovan, Rare?-Petru
, p. 1 - 26 (2021)
The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neuro-degenerative diseases. Aiming at the development of a positron emission tomography (PET) radio-tracer to monitor changes of receptor density and/or occupancy during the
Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines
Gillespie, Roger J.,Cliffe, Ian A.,Dawson, Claire E.,Dourish, Colin T.,Gaur, Suneel,Jordan, Allan M.,Knight, Antony R.,Lerpiniere, Joanne,Misra, Anil,Pratt, Robert M.,Roffey, Jonathan,Stratton, Gemma C.,Upton, Rebecca,Weiss, Scott M.,Williamson, Douglas S.
, p. 2924 - 2929 (2008/12/21)
A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A2A antagonists is described. Many examples were highly selective against the human A1 receptor sub-type and were active in an in vivo model of Parkinson's disease.
