443147-41-9

Upstream product

• 443147-39-5 7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-ethoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-heptanoic acid methyl ester 
• 95068-01-2 1-bromo-3-(ethoxymethyl)benzene 
• 443147-13-5 2-(S)-hydroxy-3-(3-ethoxymethylphenyl)propan-1-ol trityl ether 
• 443147-19-1 1-acetoxy-3-(3-ethoxymethylphenyl)-2-(S)-tetrahydropyranyloxypropane 
• 443147-33-9 1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene 
• 443147-31-7 3-(S)-t-butyldimethylsilyloxy-1-iodo-4-(3-ethoxymethylphenyl)-1-butene 
• 443147-29-3 3-(S)-t-butyldimethylsilyloxy-4-(3-ethoxymethylphenyl)-1-butyne 
• 443147-25-9 3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butyne 
• 443147-21-5 2-(S)-tetrahydropyranyloxy-3-(3-ethoxymethylphenyl)propan-1-ol 
• 443147-23-7 2-(S)-tetrahydropyranyloxy-3-(3-ethoxymethylphenyl)propan-1-al 
• 443147-17-9 2-(S)-1-acetoxy-3-(3-ethoxymethylphenyl)propan-2-ol 
• 443147-27-1 3-(S)-hydroxy-4-(3-ethoxymethylphenyl)-1-butyne 
• 443147-15-7 2-(S)-hydroxy-3-(3-ethoxymethylphenyl)propan-1-ol 

Relevant academic research and scientific papers

Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.

To identify a new selective EP4-agonist with improved chemical stability, further chemical modification of those reported previously was continued. We focused our attention on chemical modification of the alpha chain of 3,7-dithiaPGE(1) and selected 5-thi