443304-00-5

Upstream product

• 313963-50-7 (2'S,3R,4R,5S)-3-(4'-hydroxy-2'-tert-butyldimethylsilyloxy)butyl-4-N-phenyl-N-trifluoroacetamido-2,3,4,5-tetrahydro-5-methylfuran-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 313963-35-8 (E)-tert-butyl-6-benzyloxyhex-2-enoate 
• 313963-26-7 (5S)-3-[(E)-4-benzyloxybut-1-enyl]-2,5-dihydro-5-methylfuran-2-one 
• 586-96-9 Nitrosobenzene 
• 313963-41-6 (2'S,3R,4R,5S)-3-(4'-benzyloxy-2'-tert-butyldimethylsilyloxy)butyl-4-N-phenyl-N-trifluoroacetamido-2,3,4,5-tetrahydro-5-methylfuran-2-one 
• 313963-49-4 (2'R,4R,5S)-3-(4'-benzyloxy-2'-(tert-butyldimethylsilyloxy)butylidene)-4-N-phenylaminodihydro-5-methylfuran-2-one 
• 313963-40-5 (2'S,3R,4R,5S)-3-(4'-benzyloxy-2'-tert-butyldimethylsilyloxy)butyl-4-N-phenylamino-2,3,4,5-tetrahydro-5-methylfuran-2-one 
• 313963-39-2 (2'R,4R,5S)-3-(4'-benzyloxy-2'-hydroxybutylidene)-4-N-phenylaminodihydro-5-methylfuran-2-one 
• 313963-38-1 (3S,6R,9R)-6-(2'-benzyloxy)-ethyl-3-methyl-4-phenyl-1,3,4,5,6,9-hexahydro-4-aza-5-oxoisobenzofuran-1-one 

Downstream Products

• 313963-42-7 (E)-(2'S,3R,4R,5S)-3-(5'-iodo-2'-tert-butyldimethylsilyloxy)pent-4'-enyl-N-phenyl-N-trifluoroacetamido-2,3,4,5-tetrahydro-5-methylfuran-2-one 

Relevant academic research and scientific papers

The total synthesis of the annonaceous acetogenin, muricatetrocin C

The total synthesis of the potential antitumour agent muricatetrocin C has provided an ideal stage for the exploitation and development of new chemistry. A convergent synthetic strategy has been realised incorporating three distinct pieces of methodology, these include a highly diastereoselective hetero-Diels -Alder reaction to construct the butenolide terminus, an oxygen to carbon rearrangement to install the trans-2,5-disubstituted tetrahydrofuran ring and a spatial desymmetrisation process to afford the anti-diol unit.