443305-36-0

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 1072106-97-8 C₂₀H₂₄O₇ 
• 1072107-08-4 C₂₀H₂₄O₇ 
• 1373610-41-3 3-ethyl 1,1-dimethyl 3-oxo-2-phenethylpropane-1,1,3-tricarboxylate 
• 1051398-01-6 methyl 2-methoxycarbonyl-3-(3-indolyl)-3-(phenethyl)propanoate 
• 1298069-04-1 dimethyl 2-(3-phenyl-1-phenethylbut-3-enyl)malonate 
• 1298068-82-2 dimethyl 2-(1-phenethylbut-3-enyl)malonate 
• 1298068-99-1 dimethyl 2-(3-methyl-1-phenethyl-but-3-enyl)malonate 
• 1030919-40-4 dimethyl 2-((Z)-4-benzylidene-5-oxo-1-phenylhexan-3-yl)propanedioate 
• 21750-49-2 (1-Triphenylstannyl-3-phenyl-propyl)-malonsaeuredimethylester 

Relevant academic research and scientific papers

Transition metal and hydrogen bond donor hybrids: Catalysts for the activation of alkylidene malonates

Palladium ureaka! Urea palladacycles are introduced to activate alkylidene malonates for nucleophilic attack. The strategic incorporation of palladium on a urea scaffold give rise to urea catalysts with enhanced reactivity when compared to conventional ur

Indium(III)-catalyzed knoevenagel condensation of aldehydes and activated methylenes using acetic anhydride as a promoter

The combination of a catalytic amount of InCl3 and acetic anhydride remarkably promotes the Knoevenagel condensation of a variety of aldehydes and activated methylene compounds. This catalytic system accommodates aromatic aldehydes containing a variety of electron-donating and -withdrawing groups, heteroaromatic aldehydes, conjugate aldehydes, and aliphatic aldehydes. Central to successfully driving the condensation series is the formation of a geminal diacetate intermediate, which was generated in situ from an aldehyde and an acid anhydride with the assistance of an indium catalyst.

Synthesis of aminocyclobutanes by iron-catalyzed [2+2] cycloaddition

Fab Four: An iron-catalyzed [2+2] cycloaddition furnishes aminocyclobutanes with a broad range of substituents in excellent yields and diastereoselectivities. The products can be obtained on a gram scale and can be further converted to β-peptide derivatives in a few steps. Furthermore, a [4+2] cycloaddition between an aminocyclobutane and an olefin leads to the corresponding cyclohexylamines. Copyright

Ytterbium-catalyzed conjugate allylation of alkylidene malonates

Alkylidene malonates undergo efficient conjugate allylation upon treatment with allylstannanes or allylsilanes under the action of ytterbium catalysis.

A straightforward method for the synthesis of alkylidene and arylidene malonates through proline-catalyzed Knoevenagel condensation

A straightforward method for the synthesis of alkylidene/arylidene malonates and arylidene cyanoacetates, utilizing proline as an alternative to traditional catalysts is presented. A large number of unsaturated esters was obtained from the Knoevenagel reaction under very mild conditions and utilizing cheap reagents.